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Chronic obstructive pulmonary disease

2Disease-modifyingAI-generated
Burden-over-time charts — how many people this disease affects and whether that number is rising or falling — are coming to this page. The treatability read, milestones, and live trial pipeline below are current.

Milestones

dot size = significance
199020002010202020251989 — Cefixime approved (FDA)1990 — Ofloxacin approved (FDA)1990 — Fluticasone propionate approved (FDA)1991 — Cefprozil anhydrous, (e)- approved (FDA)1991 — Azithromycin approved (FDA)1991 — Clarithromycin approved (FDA)1994 — Budesonide approved (FDA)1994 — Salmeterol approved (FDA)1995 — Ceftibuten approved (FDA)1996 — Levofloxacin anhydrous approved (FDA)1997 — Cefdinir approved (FDA)1999 — Moxifloxacin approved (FDA)2001 — Formoterol approved (FDA)2001 — Telithromycin approved (FDA)2001 — Cefditoren pivoxil approved (FDA)2004 — Tiotropium approved (FDA)2006 — Arformoterol approved (FDA)2007 — Fluticasone furoate approved (FDA)2009 — Indacaterol approved (FDA)2010 — Roflumilast approved (FDA)2012 — Aclidinium approved (FDA)2013 — Vilanterol approved (FDA)2013 — Umeclidinium approved (FDA)2014 — Olodaterol approved (FDA)2018 — Revefenacin approved (FDA)2024 — Ensifentrine approved (FDA)2024
1989: Drug approval — Cefixime approved (FDA). 1990: Drug approval — Ofloxacin approved (FDA). 1990: Drug approval — Fluticasone propionate approved (FDA). 1991: Drug approval — Cefprozil anhydrous, (e)- approved (FDA). 1991: Drug approval — Azithromycin approved (FDA). 1991: Drug approval — Clarithromycin approved (FDA). 1994: Drug approval — Budesonide approved (FDA). 1994: Drug approval — Salmeterol approved (FDA). 1995: Drug approval — Ceftibuten approved (FDA). 1996: Drug approval — Levofloxacin anhydrous approved (FDA). 1997: Drug approval — Cefdinir approved (FDA). 1999: Drug approval — Moxifloxacin approved (FDA). 2001: Drug approval — Formoterol approved (FDA). 2001: Drug approval — Telithromycin approved (FDA). 2001: Drug approval — Cefditoren pivoxil approved (FDA). 2004: Drug approval — Tiotropium approved (FDA). 2006: Drug approval — Arformoterol approved (FDA). 2007: Drug approval — Fluticasone furoate approved (FDA). 2009: Drug approval — Indacaterol approved (FDA). 2010: Drug approval — Roflumilast approved (FDA). 2012: Drug approval — Aclidinium approved (FDA). 2013: Drug approval — Vilanterol approved (FDA). 2013: Drug approval — Umeclidinium approved (FDA). 2014: Drug approval — Olodaterol approved (FDA). 2018: Drug approval — Revefenacin approved (FDA). 2024: Drug approval — Ensifentrine approved (FDA)

What's being tested now

2000: 1 trials started2007: 1 trials started2008: 2 trials started2009: 2 trials started2010: 1 trials started2011: 3 trials started2012: 4 trials started2013: 2 trials started2014: 5 trials started2015: 1 trials started2016: 7 trials started2017: 5 trials started2018: 7 trials started2019: 10 trials started2020: 15 trials started2021: 20 trials started2022: 29 trials started2023: 60 trials started2024: 137 trials started2025: 225 trials started2026: 208 trials started2000201020202026225

Trials started per year, stacked by phase (darker = later phase). Source: ClinicalTrials.gov via Clin2, which tracks studies recruiting in recent years — early years undercount.

See all 692 active Chronic Bronchitis trials on Clin2 →

Related

AsthmaInterstitial lung disease and pulmonary sarcoidosisOther chronic respiratory diseases

Burden estimates: IHME Global Burden of Disease Study. Drug indications: ChEMBL (CC BY-SA). Trial data: ClinicalTrials.gov via Clin2. Velocity, acceleration, and turning points are computed by Clin2 — how this page is made. Treatability describes what medicine can do, not what is available everywhere. This page describes populations, not people, and is not medical advice.