Clin2Atlas
AtlasHeart & circulationCardiovascular diseases

Ischemic heart disease

4Curable or preventable in mostAI-generated
Burden-over-time charts — how many people this disease affects and whether that number is rising or falling — are coming to this page. The treatability read, milestones, and live trial pipeline below are current.

Milestones

dot size = significance
199020002010202020251989 — Rubidium chloride approved (FDA)1990 — Technetium sestamibi approved (FDA)1990 — Doxazosin approved (FDA)1991 — Isosorbide mononitrate approved (FDA)1991 — Ramipril approved (FDA)1991 — Simvastatin approved (FDA)1991 — Pravastatin approved (FDA)1992 — Amlodipine approved (FDA)1993 — Torsemide approved (FDA)1993 — Enoxaparin sodium approved (FDA)1993 — Perindopril approved (FDA)1993 — Abciximab approved (FDA)1995 — Carvedilol approved (FDA)1996 — Reteplase approved (FDA)1996 — Trandolapril approved (FDA)1996 — Valsartan approved (FDA)1996 — Atorvastatin approved (FDA)1996 — Alteplase approved (FDA)1997 — Clopidogrel approved (FDA)1998 — Tirofiban approved (FDA)1998 — Candesartan cilexetil approved (FDA)1998 — Eptifibatide approved (FDA)1998 — Telmisartan approved (FDA)2000 — Tenecteplase approved (FDA)2000 — Bivalirudin approved (FDA)2001 — Fondaparinux approved (FDA)2002 — Olmesartan medoxomil approved (FDA)2002 — Eplerenone approved (FDA)2003 — Rosuvastatin approved (FDA)2005 — Ivabradine approved (FDA)2006 — Ranolazine approved (FDA)2006 — Sitagliptin approved (FDA)2007 — Ammonia solution, strong approved (FDA)2008 — Rivaroxaban approved (FDA)2009 — Prasugrel approved (FDA)2010 — Ticagrelor approved (FDA)2014 — Vorapaxar approved (FDA)2015 — Evolocumab approved (FDA)2015 — Alirocumab approved (FDA)2015 — Cangrelor approved (FDA)2020 — Bempedoic acid approved (FDA)
1989: Drug approval — Rubidium chloride approved (FDA). 1990: Drug approval — Technetium sestamibi approved (FDA). 1990: Drug approval — Doxazosin approved (FDA). 1991: Drug approval — Isosorbide mononitrate approved (FDA). 1991: Drug approval — Ramipril approved (FDA). 1991: Drug approval — Simvastatin approved (FDA). 1991: Drug approval — Pravastatin approved (FDA). 1992: Drug approval — Amlodipine approved (FDA). 1993: Drug approval — Torsemide approved (FDA). 1993: Drug approval — Enoxaparin sodium approved (FDA). 1993: Drug approval — Perindopril approved (FDA). 1993: Drug approval — Abciximab approved (FDA). 1995: Drug approval — Carvedilol approved (FDA). 1996: Drug approval — Reteplase approved (FDA). 1996: Drug approval — Trandolapril approved (FDA). 1996: Drug approval — Valsartan approved (FDA). 1996: Drug approval — Atorvastatin approved (FDA). 1996: Drug approval — Alteplase approved (FDA). 1997: Drug approval — Clopidogrel approved (FDA). 1998: Drug approval — Tirofiban approved (FDA). 1998: Drug approval — Candesartan cilexetil approved (FDA). 1998: Drug approval — Eptifibatide approved (FDA). 1998: Drug approval — Telmisartan approved (FDA). 2000: Drug approval — Tenecteplase approved (FDA). 2000: Drug approval — Bivalirudin approved (FDA). 2001: Drug approval — Fondaparinux approved (FDA). 2002: Drug approval — Olmesartan medoxomil approved (FDA). 2002: Drug approval — Eplerenone approved (FDA). 2003: Drug approval — Rosuvastatin approved (FDA). 2005: Drug approval — Ivabradine approved (FDA). 2006: Drug approval — Ranolazine approved (FDA). 2006: Drug approval — Sitagliptin approved (FDA). 2007: Drug approval — Ammonia solution, strong approved (FDA). 2008: Drug approval — Rivaroxaban approved (FDA). 2009: Drug approval — Prasugrel approved (FDA). 2010: Drug approval — Ticagrelor approved (FDA). 2014: Drug approval — Vorapaxar approved (FDA). 2015: Drug approval — Evolocumab approved (FDA). 2015: Drug approval — Alirocumab approved (FDA). 2015: Drug approval — Cangrelor approved (FDA). 2020: Drug approval — Bempedoic acid approved (FDA)

What's being tested now

2000: 2 trials started2001: 1 trials started2002: 3 trials started2003: 1 trials started2004: 3 trials started2005: 1 trials started2006: 2 trials started2007: 6 trials started2008: 2 trials started2009: 3 trials started2010: 6 trials started2011: 6 trials started2012: 7 trials started2013: 12 trials started2014: 11 trials started2015: 13 trials started2016: 16 trials started2017: 19 trials started2018: 31 trials started2019: 37 trials started2020: 55 trials started2021: 74 trials started2022: 115 trials started2023: 183 trials started2024: 309 trials started2025: 378 trials started2026: 381 trials started2000201020202026381

Trials started per year, stacked by phase (darker = later phase). Source: ClinicalTrials.gov via Clin2, which tracks studies recruiting in recent years — early years undercount.

See all 1605 active Acute Coronary Syndrome trials on Clin2 →

Related

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Burden estimates: IHME Global Burden of Disease Study. Drug indications: ChEMBL (CC BY-SA). Trial data: ClinicalTrials.gov via Clin2. Velocity, acceleration, and turning points are computed by Clin2 — how this page is made. Treatability describes what medicine can do, not what is available everywhere. This page describes populations, not people, and is not medical advice.