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AtlasMental health & substance useDepressive disorders

Major depressive disorder

2Disease-modifyingAI-generated
Burden-over-time charts — how many people this disease affects and whether that number is rising or falling — are coming to this page. The treatability read, milestones, and live trial pipeline below are current.

Milestones

dot size = significance
199020002010202020251989 — Selegiline approved (FDA)1991 — Sertraline approved (FDA)1992 — Paroxetine approved (FDA)1993 — Venlafaxine approved (FDA)1994 — Nefazodone approved (FDA)1996 — Olanzapine approved (FDA)1996 — Mirtazapine approved (FDA)1997 — Quetiapine approved (FDA)1998 — Citalopram approved (FDA)2002 — Aripiprazole approved (FDA)2002 — Escitalopram approved (FDA)2004 — Duloxetine approved (FDA)2008 — Desvenlafaxine approved (FDA)2009 — Agomelatine approved (FDA)2011 — Vilazodone approved (FDA)2013 — Levomilnacipran approved (FDA)2013 — Vortioxetine approved (FDA)2015 — Brexpiprazole approved (FDA)2019 — Esketamine approved (FDA)2023 — Gepirone approved (FDA)
1989: Drug approval — Selegiline approved (FDA). 1991: Drug approval — Sertraline approved (FDA). 1992: Drug approval — Paroxetine approved (FDA). 1993: Drug approval — Venlafaxine approved (FDA). 1994: Drug approval — Nefazodone approved (FDA). 1996: Drug approval — Olanzapine approved (FDA). 1996: Drug approval — Mirtazapine approved (FDA). 1997: Drug approval — Quetiapine approved (FDA). 1998: Drug approval — Citalopram approved (FDA). 2002: Drug approval — Aripiprazole approved (FDA). 2002: Drug approval — Escitalopram approved (FDA). 2004: Drug approval — Duloxetine approved (FDA). 2008: Drug approval — Desvenlafaxine approved (FDA). 2009: Drug approval — Agomelatine approved (FDA). 2011: Drug approval — Vilazodone approved (FDA). 2013: Drug approval — Levomilnacipran approved (FDA). 2013: Drug approval — Vortioxetine approved (FDA). 2015: Drug approval — Brexpiprazole approved (FDA). 2019: Drug approval — Esketamine approved (FDA). 2023: Drug approval — Gepirone approved (FDA)

What's being tested now

2001: 1 trials started2004: 1 trials started2008: 1 trials started2012: 1 trials started2014: 3 trials started2015: 2 trials started2016: 2 trials started2017: 5 trials started2018: 2 trials started2019: 14 trials started2020: 8 trials started2021: 26 trials started2022: 26 trials started2023: 53 trials started2024: 93 trials started2025: 154 trials started2026: 151 trials started201020202026154

Trials started per year, stacked by phase (darker = later phase). Source: ClinicalTrials.gov via Clin2, which tracks studies recruiting in recent years — early years undercount.

See all 506 active Major Depression Disorder trials on Clin2 →

Related

Dysthymia

Burden estimates: IHME Global Burden of Disease Study. Drug indications: ChEMBL (CC BY-SA). Trial data: ClinicalTrials.gov via Clin2. Velocity, acceleration, and turning points are computed by Clin2 — how this page is made. Treatability describes what medicine can do, not what is available everywhere. This page describes populations, not people, and is not medical advice.