Clinical trials
Anterior Cruciate Ligament (ACL) Reconstruction clinical trials
Below are recruiting anterior cruciate ligament (acl) reconstruction clinical trials, each written for real people, not researchers. We’re tracking 115 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06662955Recruiting
Exercise with sound cues after ACL reconstruction
This study tests if adding sounds (like a metronome beat) to your rehab exercises helps your leg muscles work better after ACL reconstruction. It is for athletes who had their ACL surgery within the past 2 weeks and are ready to start moving.
Salaya, Changwat Nakhon PathomAges 18–35 - NCT06596824Recruiting
Digital training to reduce inflammation after ACL knee surgery
This trial tests a personalized digital training program for people who recently had ACL knee surgery. The goal is to see if correcting movement patterns can lower inflammation and prevent early knee arthritis.
BerlinAges 18–50 - NCT06590402RecruitingPhase 4
Nerve blocks for pain relief after kids' knee surgery
This study compares two types of nerve blocks to manage pain after knee surgery in children and teens. It is for patients aged 8 to 18 having a first-time ACL or MPFL reconstruction.
New York, New YorkAges 8–18 - NCT05342441Recruiting
Choosing the best ligament graft for ACL repair
This study looks at how different “grafts” (tissue used to rebuild the ACL) affect outcomes after first-time ACL reconstruction. It may help personalize graft choice for people who want to return to physical activity.
HvidovreAges 18–40 - NCT06561035Enrolling by invitationPhase 3
Opioid-sparing study for ACL reconstruction
This study tests pain management options after ACL reconstruction to reduce the need for strong painkillers. It may help you recover with fewer side effects and lower risk of opioid dependence.
Skokie, IllinoisAges 14–85 - NCT06529692Recruiting
Split-belt treadmill training after ACL reconstruction
This study tests whether walking on a special split-belt treadmill (where each belt moves at a different speed) can help improve how your knee moves and feels after ACL reconstruction. The goal is to see if this training leads to better long-term knee health.
Ann Arbor, MichiganAges 14–45 - NCT06511232RecruitingPhase 4
Morphine in bone for ACL surgery pain
This trial tests if giving morphine directly into the bone during ACL reconstruction can reduce pain after surgery. It may help patients who are having a specific type of ACL repair using their own patellar tendon.
Houston, TexasAges 18–40 - NCT06456268Recruiting
VibraCool to reduce pain and opioid use after ACL surgery
This trial tests a device called VibraCool to see if it can reduce pain and the need for opioid painkillers after ACL reconstruction surgery.
New York, New YorkAges Any age - NCT04295148Recruiting
Compare brace and rehab for ACL reconstruction
This study compares two ways of rehabilitating the knee after ACL rupture repair. It’s meant to see which approach helps people return to their prior sport more safely and effectively.
Stockholm, Stockholm CountyAges 16–40 - NCT06382324Recruiting
Mindfulness for knee recovery after ACL surgery
This study tests whether practicing mindfulness within the first month after ACL (anterior cruciate ligament) surgery can help with your mental well-being during recovery. You'll learn techniques to stay calm and focused.
Keelung, TaiwanAges Any age - NCT06341868Recruiting
Electrical stimulation for ACL recovery in military cadets
This trial tests whether a special electrical stimulation device (KneeStim) can help military academy cadets recover faster after ACL reconstruction surgery. It aims to improve muscle strength and knee function using gentle electrical pulses during rehabilitation.
West Point, New YorkAges 17–27 - NCT06341192Recruiting
Comparing two ways to reconstruct the ACL
This trial compares two different techniques for ACL surgery (single bundle vs. double bundle) to see which one works better. If you're planning to have ACL surgery, you may be able to join.
Taoyuan, taoyuanAges 18 years+ - NCT06357091Recruiting
ACL repair with Shark Screw or standard screw
This trial compares two types of screws used to hold a new ACL in place: a Shark Screw and a standard biocomposite screw. It may help if you have a torn ACL that needs surgery.
Schwaz, TyrolAges 18 years+ - NCT06311513RecruitingPhase 4
Concentrated bone marrow injection during repeat ACL surgery
This study tests whether adding a concentrated bone marrow injection during repeat ACL surgery helps healing and recovery better than surgery alone. If you have had a previous ACL reconstruction that failed, you may be eligible.
Atlanta, GeorgiaAges 18–55 - NCT06240780Enrolling by invitation
Incrediwear recovery study for ACL and MCL surgery
This trial tests whether wearing Incrediwear clothing helps you recover faster after arthroscopic knee surgery for ACL or MCL tears. It is designed for people about to have surgery and who want to improve their healing process.
Oklahoma City, OklahomaAges 18–65 - NCT06189573Enrolling by invitation
ACL repair: quadriceps vs patellar tendon graft
This trial compares two ways to rebuild a torn ACL using either a piece of your quadriceps tendon (with a small bone piece) or a piece of your patellar tendon (with bone). The goal is to find which graft works best for long-term stability and recovery.
Mexico City, Mexico CityAges 15–55 - NCT05949177Recruiting
Mindfulness and graded exercise for fear after ACL surgery
This trial studies whether a combination of mindfulness practice and a step-by-step return-to-activity plan can reduce fear and improve recovery after ACL reconstruction. It may help people who feel worried about re-injury and want a structured way to get back to sports.
Chapel Hill, North CarolinaAges 14–35 - NCT05754632Recruiting
Blood flow restriction exercises after ACL surgery in teens
This trial tests whether a special type of exercise that uses a cuff (blood flow restriction training, or BFRT) can help teens recover after ACL reconstruction. It’s designed to see if adding BFRT to standard rehab improves strength and return to sport.
Farmington, ConnecticutAges 12–18 - NCT05584020Recruiting
ACL repair vs. reconstruction for a recent tear
This study compares two ways to repair a torn ACL: stitching it back together (repair) versus using a graft from another tendon (reconstruction). It is for people who have a fresh, uncomplicated ACL tear and want to see which approach works better.
Hangzhou, ZhejiangAges 18 years+ - NCT05527171Recruiting
Virtual reality mindfulness after ACL knee surgery
This study uses a virtual-reality mindfulness meditation program to help improve fear and movement quality after ACL reconstruction. It may help you feel less afraid of movement and land more safely when you return to sports.
Chapel Hill, North CarolinaAges 14–25 - NCT05461326Recruiting
Compare two tendon grafts for ACL surgery recovery
This study compares two ways to rebuild the ACL using different tendon grafts (quadriceps tendon vs patellar tendon) taken from your own body. It aims to learn which option leads to better recovery after ACL reconstruction, including strength and function.
Birmingham, AlabamaAges 14–65 - NCT05391672Recruiting
Study for early surgery after a partial ACL tear
This trial looks at treatment options for people with a partial ACL ligament tear in the knee, including both recent and long-standing injuries. It may help to clarify the best early approach for healing and knee function, especially when there are no other ligament injuries.
AsyutAges 15–50 - NCT05395767Recruiting
Living-donor tendon graft for ACL repair in teens
This study tests whether an ACL reconstruction using a tendon from a living donor works well and is safe in children and teens. It may help families compare this approach while closely tracking knee function after surgery.
Pembury, KentAges 8–17 - NCT05323474Recruiting
Rehab program after ACL surgery to return to competitive sport
This study tests an “optimized” rehabilitation plan after ACL reconstruction to help people safely return to competitive sports. It’s for people who had an ACL surgery and still want to play sports that involve cutting, pivoting, or contact.
Challes-les-EauxAges 18–25
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Common questions
- Are there clinical trials for anterior cruciate ligament (acl) reconstruction?
- Yes. Clin2 currently lists 115 recruiting anterior cruciate ligament (acl) reconstruction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anterior cruciate ligament (acl) reconstruction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anterior cruciate ligament (acl) reconstruction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Anterior Cruciate Ligament Reconstruction
- Anterior Cruciate Ligament Reconstruction Rehabilitation
- ACL - Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament (ACL) Tear
- Anterior Cruciate Ligament Injuries
- Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.