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Bipolar disorder

2Disease-modifyingAI-generated
Burden-over-time charts — how many people this disease affects and whether that number is rising or falling — are coming to this page. The treatability read, milestones, and live trial pipeline below are current.

Milestones

dot size = significance
199020002010202020251993 — Risperidone approved (FDA)1994 — Lamotrigine approved (FDA)1996 — Olanzapine approved (FDA)1997 — Quetiapine approved (FDA)2001 — Ziprasidone approved (FDA)2002 — Aripiprazole approved (FDA)2009 — Asenapine approved (FDA)2010 — Lurasidone approved (FDA)2015 — Cariprazine approved (FDA)2021 — Samidorphan approved (FDA)
1993: Drug approval — Risperidone approved (FDA). 1994: Drug approval — Lamotrigine approved (FDA). 1996: Drug approval — Olanzapine approved (FDA). 1997: Drug approval — Quetiapine approved (FDA). 2001: Drug approval — Ziprasidone approved (FDA). 2002: Drug approval — Aripiprazole approved (FDA). 2009: Drug approval — Asenapine approved (FDA). 2010: Drug approval — Lurasidone approved (FDA). 2015: Drug approval — Cariprazine approved (FDA). 2021: Drug approval — Samidorphan approved (FDA)

What's being tested now

2001: 1 trials started2003: 1 trials started2008: 2 trials started2012: 1 trials started2014: 3 trials started2015: 1 trials started2016: 2 trials started2017: 5 trials started2018: 3 trials started2019: 7 trials started2020: 5 trials started2021: 14 trials started2022: 14 trials started2023: 22 trials started2024: 58 trials started2025: 70 trials started2026: 44 trials started20102020202670

Trials started per year, stacked by phase (darker = later phase). Source: ClinicalTrials.gov via Clin2, which tracks studies recruiting in recent years — early years undercount.

See all 229 active Bipolar Depression trials on Clin2 →

Related

SchizophreniaAnxiety disordersAutism spectrum disordersAttention-deficit/hyperactivity disorderConduct disorderIdiopathic developmental intellectual disabilityOther mental disorders

Burden estimates: IHME Global Burden of Disease Study. Drug indications: ChEMBL (CC BY-SA). Trial data: ClinicalTrials.gov via Clin2. Velocity, acceleration, and turning points are computed by Clin2 — how this page is made. Treatability describes what medicine can do, not what is available everywhere. This page describes populations, not people, and is not medical advice.