Clin2Atlas
AtlasDigestiveDigestive diseases

Inflammatory bowel disease

2Disease-modifyingAI-generated
Burden-over-time charts — how many people this disease affects and whether that number is rising or falling — are coming to this page. The treatability read, milestones, and live trial pipeline below are current.

Milestones

dot size = significance
199020002010202020251990 — Olsalazine approved (FDA)1994 — Budesonide approved (FDA)1998 — Infliximab approved (FDA)2000 — Isopropyl alcohol approved (FDA)2000 — Balsalazide approved (FDA)2002 — Adalimumab approved (FDA)2004 — Natalizumab approved (FDA)2008 — Certolizumab pegol approved (FDA)2009 — Ustekinumab approved (FDA)2009 — Golimumab approved (FDA)2014 — Vedolizumab approved (FDA)2020 — Ozanimod approved (FDA)2023 — Etrasimod approved (FDA)2023 — Mirikizumab approved (FDA)
1990: Drug approval — Olsalazine approved (FDA). 1994: Drug approval — Budesonide approved (FDA). 1998: Drug approval — Infliximab approved (FDA). 2000: Drug approval — Isopropyl alcohol approved (FDA). 2000: Drug approval — Balsalazide approved (FDA). 2002: Drug approval — Adalimumab approved (FDA). 2004: Drug approval — Natalizumab approved (FDA). 2008: Drug approval — Certolizumab pegol approved (FDA). 2009: Drug approval — Ustekinumab approved (FDA). 2009: Drug approval — Golimumab approved (FDA). 2014: Drug approval — Vedolizumab approved (FDA). 2020: Drug approval — Ozanimod approved (FDA). 2023: Drug approval — Etrasimod approved (FDA). 2023: Drug approval — Mirikizumab approved (FDA)

What's being tested now

2000: 1 trials started2004: 1 trials started2007: 2 trials started2008: 1 trials started2009: 3 trials started2010: 3 trials started2011: 2 trials started2012: 3 trials started2013: 4 trials started2014: 5 trials started2015: 3 trials started2016: 4 trials started2017: 10 trials started2018: 7 trials started2019: 20 trials started2020: 22 trials started2021: 45 trials started2022: 47 trials started2023: 80 trials started2024: 152 trials started2025: 227 trials started2026: 213 trials started2000201020202026227

Trials started per year, stacked by phase (darker = later phase). Source: ClinicalTrials.gov via Clin2, which tracks studies recruiting in recent years — early years undercount.

See all 825 active Crohn’s disease trials on Clin2 →

Related

AppendicitisParalytic ileus and intestinal obstructionInguinal, femoral, and abdominal herniaVascular intestinal disordersGallbladder and biliary diseasesPancreatitisOther digestive diseases

Burden estimates: IHME Global Burden of Disease Study. Drug indications: ChEMBL (CC BY-SA). Trial data: ClinicalTrials.gov via Clin2. Velocity, acceleration, and turning points are computed by Clin2 — how this page is made. Treatability describes what medicine can do, not what is available everywhere. This page describes populations, not people, and is not medical advice.