Clinical trials
Crohn’s disease clinical trials
A type of inflammatory bowel disease causing inflammation of the digestive tract. We’re tracking 333 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06051253RecruitingPhase 4
Personalized infliximab dosing for active Crohn's fistulas
This study tests whether adjusting the dose of infliximab (a biologic medicine given by IV) based on drug levels in your blood works better for treating draining fistulas caused by Crohn's disease. It is for people who have not tried other biologics and whose fistulas have not healed with usual treatments.
SeoulAges 19–80 - NCT07822087RecruitingPhase 1
Cell therapy for active crohn's disease
This trial tests an experimental cell therapy called ATORM-C for people with Crohn's disease who haven't gotten better with standard treatments. The goal is to see if this new treatment can help heal the intestinal ulcers that cause symptoms.
SeoulAges 19–80 - NCT07791862Recruiting
Early risk study for relatives of IBD patients
This study looks at healthy family members of people with Crohn's disease or ulcerative colitis to find early signs of these conditions before symptoms appear. It may help doctors predict and prevent inflammatory bowel disease.
Seattle, WashingtonAges birth–55 years - NCT07694674Recruiting
Comparing Biologic Drugs to Prevent Crohn's Return After Surgery
This trial compares different biologic medications to see which best prevents Crohn's disease from coming back after intestinal surgery. It may help you if you have had surgery for Crohn's and are starting a biologic drug soon after.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT07671872Recruiting
Testing an Anti-Inflammatory Diet for Crohn's Disease
This study tests whether a specially designed anti-inflammatory American diet can help control mild to moderate Crohn's Disease symptoms. Participants will follow a diet plan, with guidance from the research team, to see if it reduces inflammation and improves quality of life.
Miami, FloridaAges 16–75 - NCT07652632Recruiting
Regenerative endoscopy for hard-to-treat Crohn's fistulas
This trial tests a new, less invasive procedure called regenerative endoscopy to repair complex fistulas in people with Crohn's disease. It's for those who haven't gotten better with standard treatments like biologics or surgery.
Hyderabad, TelanganaAges 18–65 - NCT07636304Enrolling by invitationEarly Phase 1
Brain stimulation for inflammatory bowel disease remission
This study tests whether a non-invasive device that stimulates the vagus nerve (a major nerve in your neck) can affect brain function in people whose IBD is in remission. Researchers want to understand if this stimulation might help reduce inflammation or improve symptoms in the future.
Gdansk, Pomeranian VoivodeshipAges 18 years+ - NCT06059989RecruitingPhase 3
Testing a new form of infliximab for Crohn's disease
This trial is testing a new way to give infliximab, a treatment for moderate to severe Crohn's disease, as a shot under the skin. It's for people who haven't gotten better with other treatments or need strong medication right away.
Amsterdam, North HollandAges 18–80 - NCT05974358Recruiting
Compare two bowel-connection methods to prevent Crohn’s flare-ups
This trial tests whether a specific type of bowel connection during Crohn’s surgery can lower the chances that the disease comes back. It may help people having their first ileocolonic (small-to-large bowel) surgery for certain Crohn’s complications.
BesançonAges 18–75 - NCT07314606Recruiting
Diet plus infliximab for kids with Crohn’s
This study tests if a special diet (called CDED) combined with infliximab (a biologic drug) is more effective than infliximab alone for children with newly diagnosed or relapsed moderate-to-severe Crohn’s disease. It aims to improve gut healing and reduce inflammation.
Vancouver, British ColumbiaAges 9–17 - NCT07273188RecruitingEarly Phase 1
PET scan to measure gut scarring in Crohn's disease
This study tests a new PET scan with a tracer called 68Ga-FAPI-46 to see how well it can find and measure scarring (fibrosis) in the small bowel caused by Crohn's disease. It may help doctors better understand and manage bowel damage.
Rochester, MinnesotaAges 18 years+ - NCT07231601Recruiting
Laparoscopic surgery for Crohn's disease of the small intestine
This trial tests a specific laparoscopic (keyhole) surgery technique for Crohn's disease affecting the last part of the small intestine. It aims to see if removing more of the fatty tissue around the bowel leads to better outcomes. If you have Crohn's disease needing surgery in this area, you may be eligible.
Piraeus, AtticaAges 16 years+ - NCT06890637Recruiting
Fecal transplant and diet change for Crohn's disease
This trial tests whether a fecal transplant (putting healthy bacteria into your gut) combined with dietary changes can help control active Crohn's disease. It is for people who need stronger treatments or have stopped responding to their current therapy.
Kochi, KeralaAges 18–75 - NCT06890650Recruiting
Fecal transplant and diet for new Crohn's disease
This study tests whether a combination of fecal transplant (transferring healthy bacteria from a donor) and dietary changes can help control disease activity in people newly diagnosed with Crohn's. It is for those with mild to moderate symptoms who have not yet taken any Crohn's medications.
Kochi, KeralaAges 18–75 - NCT04187820Recruiting
Acupuncture for mild to moderate Crohn’s flare
This trial tests whether acupuncture can help calm an active Crohn’s disease flare that is mild to moderate. It may be an option if standard Crohn’s medicines like steroids, immunosuppressors, and anti-TNF drugs are not working for you or you can’t tolerate them.
Shanghai, Shanghai MunicipalityAges 16–70 - NCT06871267Recruiting
Dietary changes for mild to moderate Crohn's disease
This study looks at how changing your diet might help people with Crohn's disease feel better. It is for adults with mild to moderate Crohn's who are not using a liquid-only diet and have not had recent surgery.
Kuala Lumpur, Petaling JayaAges 18–50 - NCT06925061RecruitingPhase 2
Testing EXL01 to prevent Crohn's disease return after surgery
This study tests a new oral treatment called EXL01 to see if it can prevent Crohn's disease from coming back after surgery to remove part of the small and large intestine. It may be an option if you are not planning to use strong immune-suppressing drugs (except anti-TNF) in the next 6 months.
Clermont-FerrandAges 18 years+ - NCT06896305Recruiting
Adding a Special Diet to Anti-TNF Therapy for Crohn's and Colitis
This study tests whether adding a special diet (the Crohn's Disease Exclusion Diet) to standard anti-TNF medicine works better than the medicine alone for people with moderate to severe Crohn's disease or ulcerative colitis. You would be asked to follow a specific meal plan for several weeks while taking your regular medication.
Milan, MichiganAges 18 years+ - NCT06538649RecruitingEarly Phase 1
Testing statins for Crohn's disease before and after surgery
This study tests whether taking a statin (a cholesterol-lowering medicine) before and after surgery for Crohn's disease can help improve outcomes. It's for people with a specific type of Crohn's that causes narrowing in the small intestine and who are already scheduled for surgery.
Stanford, CaliforniaAges 18–80 - NCT06332534RecruitingPhase 3
Upadacitinib in children with moderate to severe Crohn's disease
This study tests an oral pill called upadacitinib for children with moderate to severe Crohn's disease that hasn't responded well to other treatments. It aims to see if the medicine can reduce inflammation and improve symptoms safely.
Oakland, CaliforniaAges 2–17 - NCT06257706RecruitingPhase 4
Healing the bowel wall in Crohn's disease with vedolizumab
This study tests whether a medicine called vedolizumab can help heal all layers of the bowel wall in Crohn's disease. It uses a special ultrasound to see inside the bowel, aiming for deeper healing than usual.
Los Angeles, CaliforniaAges 18–80 - NCT06274554RecruitingPhase 3
Testing Antifungal Therapy for Crohn's Disease
This study tests whether adding an antifungal drug (fluconazole) to standard Crohn's disease treatment helps improve symptoms. It's for people with mild to moderate Crohn's who have not used antifungal medications recently.
New York, New YorkAges 18 years+ - NCT06226883RecruitingPhase 2
Testing MORF-057 for moderate to severe Crohn's disease
This study tests an oral medicine called MORF-057 for people with moderate to severe Crohn's disease. It aims to see if the drug can reduce inflammation and improve symptoms for those who haven't had success with other treatments.
Lancaster, CaliforniaAges 18–85 - NCT06146816Recruiting
Infrared light therapy for Crohn's disease
This trial tests a new infrared light treatment to see if it can reduce inflammation and symptoms in people with Crohn's disease. It's for those who have active disease despite current treatments or who are not on therapy.
Tel AvivAges 18–80
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Crohn’s disease trials by city
Studies with a site in or near these metro areas.
Crohn’s disease trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for crohn’s disease?
- Yes. Clin2 currently lists 333 recruiting crohn’s disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a crohn’s disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a crohn’s disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.