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Migraine

3Curable in someAI-generated
Burden-over-time charts — how many people this disease affects and whether that number is rising or falling — are coming to this page. The treatability read, milestones, and live trial pipeline below are current.

Milestones

dot size = significance
199020002010202020251992 — Sumatriptan approved (FDA)1996 — Topiramate approved (FDA)1997 — Zolmitriptan approved (FDA)1998 — Rizatriptan approved (FDA)1998 — Naratriptan approved (FDA)1998 — Celecoxib approved (FDA)2001 — Almotriptan approved (FDA)2001 — Frovatriptan approved (FDA)2002 — Eletriptan approved (FDA)2018 — Galcanezumab approved (FDA)2018 — Erenumab approved (FDA)2018 — Fremanezumab approved (FDA)2019 — Botulinum toxin type a approved (FDA)2019 — Ubrogepant approved (FDA)2020 — Eptinezumab approved (FDA)2020 — Rimegepant approved (FDA)2020 — Lasmiditan approved (FDA)2021 — Atogepant approved (FDA)2023 — Zavegepant approved (FDA)
1992: Drug approval — Sumatriptan approved (FDA). 1996: Drug approval — Topiramate approved (FDA). 1997: Drug approval — Zolmitriptan approved (FDA). 1998: Drug approval — Rizatriptan approved (FDA). 1998: Drug approval — Naratriptan approved (FDA). 1998: Drug approval — Celecoxib approved (FDA). 2001: Drug approval — Almotriptan approved (FDA). 2001: Drug approval — Frovatriptan approved (FDA). 2002: Drug approval — Eletriptan approved (FDA). 2018: Drug approval — Galcanezumab approved (FDA). 2018: Drug approval — Erenumab approved (FDA). 2018: Drug approval — Fremanezumab approved (FDA). 2019: Drug approval — Botulinum toxin type a approved (FDA). 2019: Drug approval — Ubrogepant approved (FDA). 2020: Drug approval — Eptinezumab approved (FDA). 2020: Drug approval — Rimegepant approved (FDA). 2020: Drug approval — Lasmiditan approved (FDA). 2021: Drug approval — Atogepant approved (FDA). 2023: Drug approval — Zavegepant approved (FDA)

What's being tested now

2014: 1 trials started2016: 1 trials started2017: 1 trials started2018: 2 trials started2019: 4 trials started2020: 5 trials started2021: 14 trials started2022: 14 trials started2023: 32 trials started2024: 55 trials started2025: 65 trials started2026: 79 trials started2020202679

Trials started per year, stacked by phase (darker = later phase). Source: ClinicalTrials.gov via Clin2, which tracks studies recruiting in recent years — early years undercount.

See all 246 active Migraine Headache trials on Clin2 →

Related

Tension-type headache

Burden estimates: IHME Global Burden of Disease Study. Drug indications: ChEMBL (CC BY-SA). Trial data: ClinicalTrials.gov via Clin2. Velocity, acceleration, and turning points are computed by Clin2 — how this page is made. Treatability describes what medicine can do, not what is available everywhere. This page describes populations, not people, and is not medical advice.