Migraine Headache clinical trials

MySalvia system for resistant migraine

This trial tests a device called MySalvia that is implanted in the head to reduce migraine attacks. It is for people whose migraines have not improved with at least three different preventive treatments.

Mind-body balance program for children with migraine

This trial studies a mind-body balance approach to help reduce symptoms and disability from pediatric migraine. You may join if your child has migraine headaches and can follow study routines, including keeping a headache diary.

Behavior program for chronic migraine

This trial tests a behavioral (talk/skills-based) program to help people with chronic migraine. It may help reduce migraine frequency or improve day-to-day coping.

Study of treatments for childhood migraine headaches

This study looks at ways to help children and teens with migraine headaches by testing a care approach that includes access to evidence-based treatment. It may help if your child has frequent migraine headaches and is starting (or not already on) certain migraine-preventive medicines.

Comparing biodegradable vs. metal heart-hole closures for migraine

This trial compares two types of devices (biodegradable vs. metal) to close a small hole in the heart (PFO) in people who have migraine not controlled by usual treatments. It aims to see which device works better to reduce migraine attacks.

Nerve-stimulation device for headache in children and young adults

This trial tests if a gentle nerve-stimulating device worn on the neck (called nVNS) can prevent and treat common headaches like migraine, cluster, and tension-type headaches in children and young adults. If you often get headaches and want a drug-free option, this might help.

Headache disorder registry for teens and adults with primary headaches

This study is a headache disorder registry that enrolls people with common, “primary” headache types such as migraine or tension headache, including some with medication-overuse headaches. It collects information to better understand these conditions and who they affect.

Migraine study measuring CGRP levels by age and sex

This study measures a substance called CGRP in saliva from people with migraine and healthy volunteers to see how it changes with age and sex. It may help researchers understand migraine better.

Exercise study for women with migraine

This study tests whether aerobic exercise can help reduce migraine symptoms and improve how your body senses and responds to pain. It is specifically for women aged 18–48 who have migraine headaches 3–8 days per month.

Virtual reality for headache relief in kids

This study tests if using virtual reality to learn relaxation techniques can help reduce headaches in children and teens who have migraines or frequent tension headaches.

Can oral caffeine help with acute migraine attacks?

This trial tests whether taking caffeine by mouth can reduce the severity of a migraine attack when it happens. It may offer a simple, at-home option for people with different types of migraine.

New tools to track migraine prevention

This study tests new ways to monitor how well preventive migraine treatments are working. It is for people with chronic migraine who may be starting or already using preventive medications.

Migraine attack prediction study using smartphone tracking

This study uses a smartphone app or device to track your body signals and predict when a migraine attack is about to start. It is designed for people with frequent (10–14 days per month) migraines.

Yoga for chronic migraine and cluster headache

This study tests whether yoga-based movements can help reduce headache frequency and improve well-being in people with chronic migraine or cluster headache. You would follow online or in-person yoga instructions at home for several weeks, wear an activity tracker, and provide blood samples.

Neuro supplements for migraine prevention

This trial tests whether a combination of vitamins and supplements can help prevent migraines. It's for adults who have migraines often (at least 6 days per month) and want to try a non-drug option.

Headache and dizziness registry for people with headache disorders

This study is a registry, meaning it collects information over time about people with headaches (including migraine, tension-type, and some dizziness-related headaches). It may help researchers better understand these conditions and plan future studies.

Bilateral artery embolization for chronic migraine

This trial tests a procedure called bilateral middle meningeal artery embolization to see if it reduces chronic migraine symptoms in people who haven't found relief from other treatments. It's for those with frequent, disabling migraines that affect both sides of the head.

Headache diary for migraine patients

This trial tests whether a headache diary can help people with migraine track their symptoms and improve their care.

International headache registry for people with headache diagnoses

This study collects information from people who have headaches to better understand different headache types. You may help researchers by keeping headache records and allowing follow-up over time.

High- vs Standard-Dose Intravenous Magnesium for Acute Headache

Evaluating migraine treatment designs

This trial is testing new ways to treat migraine attacks. It is for adults in Denmark who have migraine on a few days each month and have used triptan rescue medicines.

Study on new migraine drugs in real life

This study tracks how well new migraine medications (like Aimovig, Emgality, Ajovy, Vyepti, Qulipta, and Nurtec) work in everyday use. It may help you and your doctor understand if these treatments are a good option for your migraines.

Group therapy with exercise for teens with migraine

This study tests a group therapy program for teens with migraine. The program combines physical activity, muscle relaxation, and education about migraines. It aims to help teens manage their headaches better.

Muscle function and tenderness in headache patients

This study looks at how your neck and shoulder muscles work and feel tender if you have frequent headaches (at least 10 days per month). The researchers want to see if there are differences in muscle function and tenderness between people with migraine, tension-type headache, or posttraumatic headache.