Fecal transplant study for severe alcoholic hepatitis safety
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether fecal microbiota transplantation (a controlled transfer of stool bacteria) is safe in people with severe alcoholic hepatitis. It aims to see if the treatment is tolerable and what risks may come with it, in addition to watching how liver illness changes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 to 75 years old
- Have alcoholic hepatitis that started with yellowing of the skin within the last 8 weeks
- Have continued heavier alcohol use for at least 6 months, with less than 60 days of stopping before jaundice
- Have lab tests showing severe liver disease (for example, very high bilirubin and a high MELD or Maddrey score)
- Not have other causes of liver disease besides alcohol
- No uncontrolled infection or sepsis, and no active gastrointestinal bleeding
- Not have pregnancy or breastfeeding, severe swallowing problems, major gut blockage/surgery in the last year, or recent shunt/port placement
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial is looking at bacteria inside the liver of people with alcoholic hepatitis. It may help understand how these bacteria affect the disease and lead to better treatments.
This trial tests whether a fecal microbiota transplant (FMT) can help people with alcohol-related cirrhosis who are still drinking. It aims to see if FMT can reduce alcohol cravings and improve liver health.
This trial tests whether transplanting healthy gut bacteria (from donor stool) can improve outcomes in people with cirrhosis. If you have mild to moderate cirrhosis, you may be able to join.
This study tests whether stool from healthy donors can help people with advanced liver disease (cirrhosis) who have had complications like fluid buildup. You would receive the transplant through a colonoscopy or enema.
This trial looks at the gut bacteria (microbiome) in people with severe alcoholic hepatitis to understand how it affects the illness. It may help doctors find better ways to treat this condition.
This trial studies whether transferring healthy gut bacteria (from a donor sample) can improve outcomes for people with liver cirrhosis who have worsening complications. It may help by changing the gut microbiome, which can influence inflammation and liver health.
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