Regorafenib with or without targeted immunotherapy and radiation for spread colon cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This Phase 2 study tests whether taking regorafenib alone or with immunotherapy (toripalimab) and a lower-dose radiation plan can better control metastatic colon or rectal cancer that has MSS/pMMR. It may help by combining cancer-blocking medicine with immune activation and focused radiation to metastatic spots.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 18 or older
- Your overall condition is fair: ECOG 0–1
- You have MSS/pMMR adenocarcinoma of the colon or rectum confirmed by biopsy
- Your cancer has spread to at least one spot that can be targeted with radiation, and it has been checked as measurable by RECIST 1.1
- Your cancer has already tried (or couldn’t tolerate) standard first- and second-line treatments
- You haven’t had earlier regorafenib or immunotherapy like anti–PD-1/anti–PD-L1 before
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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