Clinical trials · Massachusetts
Depression - Major Depressive Disorder clinical trials in Massachusetts
We’re tracking 10 recruiting depression - major depressive disorder studies with a site in Massachusetts — including Phase 2 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT05962879Recruiting
Program for teens with early psychosis-like experiences
This trial tests a new mental health program for teenagers who are having at least one psychosis-like experience and may be at risk for serious mental illness. It may help by offering structured support for both teens and their parents.
Boston, MassachusettsAges 14–19 - NCT05837104RecruitingPhase 2
Magnesium and vitamin B6 for early bipolar depression
This Phase 2 trial tests whether magnesium plus vitamin B6 can reduce depressive symptoms in people who are newly diagnosed with bipolar I disorder. It also checks for safety over a short, 4-week treatment period.
Belmont, MassachusettsAges 18–50 - NCT05567640Recruiting
Smart digital mental health support
This study tests a digital mental health program that uses smart technology to personalize your experience and keep you engaged. If you join, you may get a more tailored approach to improving your mental well-being.
Boston, MassachusettsAges 18 years+ - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT07359157Recruiting
Support program for WRCH patients with legal history
This study offers a group program at Worcester Recovery Center and Hospital (WRCH) aimed at helping people who have been involved with the legal system. It is designed for current patients at WRCH who are at least 18 years old and comfortable speaking English.
Worcester, MassachusettsAges 18 years+ - NCT07250061Recruiting
Self-help PTSD program for women veterans
This study tests a self-guided program to help women veterans with PTSD. You would work through coping skills on your own, with support from a group of other women veterans.
Boston, MassachusettsAges 18 years+ - NCT05555875Recruiting
Study how people engage with digital mental health tools
This study looks at what helps (or prevents) people from using digital mental health programs. You may join if you have meaningful depression and/or anxiety symptoms and you can use a smartphone for the study apps.
Boston, MassachusettsAges 18–75 - NCT06790641Recruiting
Supporting mental health during and after pregnancy
This study aims to improve mental health care for people during and after pregnancy. It involves interviews or focus groups with healthcare providers, peer mentors, and patients to understand how to make support services more helpful and accessible.
Shrewsbury, MassachusettsAges 18–70 - NCT05624931Recruiting
Helping pregnant women stay on PrEP after starting it
This study tries to reduce the psychological barriers that make it hard for pregnant or postpartum women to keep taking PrEP. It may help by offering support tailored to stress, trauma symptoms, or depression—especially soon after PrEP is started.
Boston, MassachusettsAges 15 years+ - NCT07220460RecruitingPhase 2
Study of an oral drug for bipolar depression
This trial tests an experimental pill (ABB-932) for people with bipolar I or II disorder who are currently in a depressive episode. The goal is to see if the drug is safe and helps improve mood.
Springfield, MassachusettsAges 18–65
Depression - Major Depressive Disorder trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting depression - major depressive disorder studies listed above.
- McLean Hospital · 2 studies
- Boston University
- Center for Anxiety and Related Disorders, Boston University
- Elixia Health
- Fully online study
- Jessica Morrow Lipschitz
- Massachusetts General Hospital
- UMass Chan Medical School
What taking part in a depression - major depressive disorder study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression - Major Depressive Disorder trials in other states
Common questions
- Are there depression - major depressive disorder clinical trials in Massachusetts?
- Yes. We're currently tracking 10 recruiting depression - major depressive disorder studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression - major depressive disorder study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression - major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression - major depressive disorder studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.