MIBG radioactive iodine treatment for hard-to-treat childhood tumors
Part of Cancer clinical trials.
This trial studies a radioactive medicine called iodine I-131 MIBG to shrink tumors that take up MIBG. It may help people whose neuroblastoma or malignant pheochromocytoma/paraganglioma has come back, progressed, or not responded to standard treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have neuroblastoma (NB) or malignant pheochromocytoma/paraganglioma, confirmed by the study’s testing rules
- Your scans show tumors that “light up” on an MIBG scan (MIBG-avid) and there is measurable disease
- Your cancer has grown, come back, or not fully responded to usual treatments
- You are old enough: NB must be over 1 year; malignant pheochromocytoma/paraganglioma must be 1–21 years
- You can safely follow radiation safety rules during treatment, and you can come for the study visits
- If you need the higher-dose option, you must have stem cells saved to bring back after treatment
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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