Study of how off-label medicines work in young children

This study measures how children’s bodies handle medicines they are already prescribed as standard care. It may help doctors choose safer, more accurate doses for children in the future.

This trial measures how the study medicines move through the body and how they affect the child in the Pediatric Cardiac Intensive Care Unit. It may help doctors choose safer and better dosing for critically ill children.

This study follows adults with cancer who are receiving anti-cancer medicines that are being used “off-label” (not exactly as the usual label says). It aims to learn about how these treatments are used in real life and what outcomes people experience.

This trial studies how certain anti-infective medicines (for bacterial and fungal infections) move through the body in children. The goal is to use that information to improve how these medicines are dosed and used safely in pediatric care.

This study follows children who take medicines to better understand what causes side effects. It also looks at family history and genetics to see who may be more likely to have an adverse reaction, and it checks findings using adults.

This trial helps children, teens, and young adults get an innovative cancer medicine when their disease has returned or hasn’t responded—and standard options are not available. It checks whether a “compassionate use” or off-label medicine plan can be carried out safely for the people who need it.