Clin2
NCT04295863Possibly a fitRecruiting

Test different dosing schedules for two immunotherapy drugs

Metastatic Cancer

Part of Cancer clinical trials.

This early trial compares how often two immune system medicines—nivolumab and pembrolizumab—are given for advanced or metastatic cancers. It aims to see which dosing interval is workable and safe for people needing treatment.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
264 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have a locally advanced or metastatic cancer where your doctor recommends nivolumab or pembrolizumab
  • You are 18 years old or older
  • Your cancer can be measured on scans to track response
  • You have not previously received immune checkpoint drugs like nivolumab or pembrolizumab
  • Your planned treatment will not include ipilimumab or any anti-CTLA-4 antibody together with nivolumab or pembrolizumab

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07394062Recruiting
Comparing chemo-immunotherapy combinations for advanced lung cancer

This study compares two standard treatments for metastatic non-small cell lung cancer when the tumor has low levels of a protein called PD-L1. It looks at how well chemotherapy plus pembrolizumab works versus chemotherapy plus nivolumab and ipilimumab.

Ankara
NCT05498792Recruiting· Early Phase 1
Trial testing CBL0137 with two immunotherapy drugs for melanoma

This early trial tests CBL0137 along with ipilimumab and nivolumab (two immune-based cancer medicines) in people with stage III or possibly stage IV melanoma that can be biopsied. It may help shrink melanoma and improve immune control, while also learning how safe and effective this combination is.

Philadelphia, Pennsylvania
NCT07174453Recruiting· Phase 3
Comparing side effects of different doses of immunotherapy

This study compares standard dosing schedules of pembrolizumab or nivolumab (two immunotherapy drugs) to see which one causes fewer immune-related side effects. It is for people with solid tumors who are already eligible to receive one of these drugs as part of their standard care.

Westwood, Kansas
NCT06561386Recruiting· Phase 3
Testing a new drug combo for advanced lung cancer

This trial is comparing a new combination of two immunotherapy drugs (nivolumab and relatlimab) plus chemotherapy against the standard immunotherapy (pembrolizumab) plus chemotherapy for people with advanced non-squamous non-small cell lung cancer that has a certain protein (PD-L1) on at least 1% of its cells. The goal is to see if the new combination works better.

Mobile, Alabama
NCT07615881Not yet recruiting· Phase 1/Phase 2
Comparing ways to give immunotherapy for advanced melanoma

This study tests a new way of giving a combination of two immunotherapy drugs (ipilimumab and nivolumab) for advanced melanoma. The drugs are given either into a vein or into the skin, to see if the skin injection works as well and causes fewer side effects.

NCT06364917Recruiting· Phase 2
Comparing two immunotherapy options for PD-L1 negative lung cancer

This trial tests whether using two immunotherapy drugs together works better than a single drug for people with advanced non-small cell lung cancer that does not have the PD-L1 protein. The study aims to find a more effective treatment for this specific type of lung cancer.

Birmingham, Alabama

Hear when a new Metastatic Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.