DaRT radiation plus pembrolizumab for head and neck cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests whether a targeted internal radiation treatment (DaRT) combined with pembrolizumab (an immune therapy) can shrink recurrent or metastatic head and neck squamous cell cancer that cannot be fully removed with surgery. It may help by making cancer more visible to the immune system while delivering localized radiation to a tumor area.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have head and neck squamous cell cancer that is recurrent or has spread and cannot be fully removed by surgery
- Your doctor must be able to place the DaRT “seeds” safely in a tumor spot that is technically suitable
- You must be able to provide tumor tissue (from stored tissue or a new biopsy)
- You must be an adult (18+) with good enough body strength (ECOG 0–2) and expected survival over 6 months
- Blood tests must meet minimum levels (white blood cells, platelets, and hemoglobin) and kidney/liver function must be adequate
- You must not have certain prior treatments, immune conditions, infections (like active TB or hepatitis), or brain metastases
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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