Cell therapy for repeated viral infections after transplant
Part of Infections clinical trials.
This early-phase (Phase 1) study tests an immune cell treatment (R-MVST) to help people whose immune system has been weakened by a past transplant and who keep getting viral infections reactivated or not responding well to standard treatment. It may help your body control viruses like EBV, CMV, adenovirus, or BK virus.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 18 or older.
- You had a transplant (HCT or SOT) and now have viral reactivation or viral infection causing illness in the body (end-organ or whole-body symptoms), and standard treatments didn’t work well enough.
- You have repeat or multiple viral problems—more than one episode or more than one virus reactivating/symptomatic—and at least one required treatment; some viruses (adenovirus/BK) can count even if there’s no standard treatment.
- You do NOT have other uncontrolled infections besides EBV, CMV, adenovirus, or BK (bacterial/fungal infections must be stable and not getting worse for a set time before infusion).
- You cannot be using certain immune-suppressing medicines or recent related immune treatments, including higher-dose steroids, anti-T-cell antibodies (like ATG/alemtuzumab), or methotrexate/immunosuppressants that suppress T-cell growth.
- You must not have serious transplant complications (like high-grade GVHD), active uncontrolled cancer relapse, be pregnant/breastfeeding, or be unable to follow study visits and procedures.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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