Testing pirfenidone to treat severe acute pancreatitis
Treatments studied
Part of Digestive system clinical trials.
This early-stage hospital study tests whether pirfenidone is safe and tolerable for people with acute pancreatitis that may become severe. It may help by reducing the risk of complications, while researchers carefully track side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 85 years old
- You were admitted for acute pancreatitis, based on lab tests and/or imaging and typical upper belly pain
- You can start study drug or placebo within 48 hours of your pancreatitis diagnosis
- Your doctors think your pancreatitis is likely to become moderate or severe
- Your liver and kidney tests are not too abnormal (especially AST/ALT, bilirubin, and kidney filtration)
- You can take part even if you have other illnesses, but you must not have key exclusions like chronic pancreatitis or recent prior pancreatitis
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a special blood filter (Efferon LPS) can help people with moderate to severe acute pancreatitis by removing harmful substances. It is for those who have been sick for 5 days or less and have certain signs of inflammation or organ stress.
This trial tests whether pioglitazone or empagliflozin is better at managing diabetes caused by chronic or recurrent pancreatitis. You will take one of these pills daily for 6 months and track your blood sugar and ketones at home. The goal is to find a safer, more effective treatment for this type of diabetes.
This trial studies whether periods of intermittent fasting can help people with recurrent pancreatitis. It may be aiming to improve pancreas-related function and symptoms, especially in people with ongoing digestive enzyme problems.
This trial compares three common pain relievers (paracetamol, ibuprofen, and metamizole) to see which works best for children with acute pancreatitis. It aims to help your child feel better faster with fewer side effects.
This trial tests if pirfenidone, an anti-scarring drug, can reduce the number of repeat episodes of acute pancreatitis. You may be eligible if you've had two or more pancreatitis attacks at least three months apart and are not having an active attack right now.
This trial tests whether pirfenidone, an oral medication that may reduce scarring and inflammation, can help relieve pain in people with chronic pancreatitis. If you have ongoing pain or frequent flare-ups, this study could offer a new treatment option.
Hear when a new Pancreatitis, Acute trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.