Biopsy-guided cervical procedure for persistent high-risk HPV
Part of Cancer, Infections, Women’s health & pregnancy clinical trials.
This study looks at doing a diagnostic cervical conization (a cone-shaped tissue biopsy) when HPV remains persistent and there are warning signs, but initial pathology does not show precancer. It aims to find hidden precancer earlier or better understand HPV-related changes that were missed.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You were referred for colposcopy and cervical biopsy because your screening test was abnormal, and the biopsy showed no precancer lesions
- Your clinician suspects precancer based on one or more risk signs (such as long-lasting HPV 16/18 infection, high HPV “integration” reading, or suspicious colposcopy findings)
- Your HPV or test results must match specific higher-risk patterns (for example TCT results like ASC-H or HSIL, or certain cell changes)
- You are not pregnant
- You do not have suspected vaginal precancer, ongoing untreated cancers in other body systems, or active (acute) genital/anal infections
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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