Safety and early benefits of an injection plus radiation for cervical cancer
Treatments studied
Part of Cancer, Women’s health & pregnancy clinical trials.
This Phase 1 study tests whether KRC-01, given by injection into the tumor, is safe and tolerable when combined with standard chemoradiation for locally advanced cervical cancer. It also looks for early signs that the treatment can shrink tumors.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 years or older and able to sign informed consent before any study steps
- Have cervical cancer in the uterus cervix that was confirmed by biopsy as squamous cell, adenocarcinoma, or adeno-squamous
- Have stage II or III cancer that has not spread to distant organs (no metastases)
- Have a measurable tumor larger than 5 cm that is reachable for injection and has not been previously irradiated
- Be able to start and complete radiation plus cisplatin treatment within about 8 weeks, with planned external-beam radiation (EBRT) and then brachytherapy (BT)
- Be physically able for treatment (ECOG 0 or 1) and able to avoid pregnancy during treatment and for 3 months after
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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