ctDNA-guided chemotherapy after colon cancer surgery
Part of Cancer, Digestive system clinical trials.
This trial checks whether a special blood test (ctDNA methylation) can help decide the best chemotherapy after surgery for people at higher risk of colon cancer coming back. It may help spare some patients unnecessary treatment while aiming to improve outcomes for those likely to relapse.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You were diagnosed with colon cancer (colon adenocarcinoma).
- You had curative surgery to remove the main tumor, with no clear relapse on scans after surgery.
- Your cancer is stage II or III but labeled “high-risk” based on final tumor/pathology results.
- A blood test taken 5–7 days after surgery was positive for ctDNA methylation.
- You are 18–80 years old and expected to live more than 12 months.
- You are well enough to receive treatment (ECOG 0–1) and your blood/organ tests meet set limits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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