Antibiotics for chronic back pain with Modic changes
Treatments studied
Part of Pain clinical trials.
This trial tests whether an antibiotic (amoxicillin) can reduce chronic low back pain in people who have a specific type of bone change (Modic type I) after a past herniated disc. If you qualify, you would receive either the antibiotic or a placebo (inactive pill) for several weeks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have had low back pain for more than 6 months, and it started after a herniated disc that was confirmed by MRI.
- Your average pain level in the last 2 weeks is at least 5 out of 10.
- You have a specific type of bone change (called Modic type I) near the old herniated disc, seen on an MRI.
- You answer 'Yes' to at least 2 of these: pain gets worse with exercise, pain wakes you at night, turning in bed hurts, or morning pain.
- You are not allergic to penicillin, not pregnant, and have not had antibiotics or back surgery in the last month.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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