Laser with methotrexate cream for vitiligo
Part of Skin clinical trials.
This trial tests whether applying a methotrexate lotion after a special laser treatment (fractional CO2 laser) can help repigment vitiligo patches better than the lotion alone. The laser makes tiny holes in the skin so the medicine may absorb more deeply.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have non-segmental vitiligo (patches on both sides of your body) that has been stable for at least 6 months.
- You have similar-sized vitiligo patches on both sides of your body (so one side can be treated with the laser and medicine, the other side with medicine alone).
- You have not used steroid creams or light therapy for your vitiligo in the last 3 months.
- You are not pregnant, have no other serious organ problems, and have no other skin diseases.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a new combination treatment (microneedling plus a non-steroidal ointment called crisaborole) can help repigment patches of vitiligo that have been stable for a while. It is for people with non-segmental vitiligo that is not spreading.
This trial tests a new gel made from stem-cell substances (secretome) given with narrow-band UVB light therapy for stable non-segmental vitiligo. It compares two ways of applying the gel to see which works better.
This trial tests an ointment called MH004 to see if it helps repigment white patches in people with non-segmental vitiligo (the most common type). It focuses on patches on the face and body.
This trial tests whether taking small doses of steroids by mouth for a few days before and after a skin cell transplant (NCES) can reduce the white halo that sometimes forms around the treated area. It is for people with stable vitiligo on the face or trunk that hasn't responded to creams or light therapy.
This study tests two ways of delivering methotrexate to help restore color in vitiligo patches: one uses a special gel, the other uses a mild electrical current (iontophoresis) to push the medicine into the skin. It might help if your vitiligo has been stable for at least 6 months and you haven't used other treatments recently.
This trial tests two topical creams (one is a natural amino acid, the other is a chemotherapy-like drug) applied after a laser treatment to see which works better for restoring color in vitiligo patches. It may help if you have focal vitiligo and are otherwise healthy.
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