Short course steroids for severe alcohol-related hepatitis
Treatments studied
Part of Digestive system, Infections clinical trials.
This trial tests whether a short course of steroids (anti-inflammatory medication) can help people with severe alcohol-associated hepatitis. It aims to see if this treatment improves liver function and survival.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 80 years old.
- You have been diagnosed with alcohol-associated hepatitis (a severe liver inflammation from heavy drinking).
- Your liver disease is severe (MELD score above 21 or mDF score above 32).
- If you have an infection, it must be well controlled (no fever, sterile cultures, low procalcitonin).
- You cannot have active bleeding, kidney problems, other liver diseases, HIV, or uncontrolled diabetes.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving corticosteroids for a longer time, or adding a medicine called N-acetylcysteine, can help people with severe alcoholic hepatitis. It is for patients who have been drinking heavily and recently developed jaundice.
This trial compares two treatments for alcoholic hepatitis: mycophenolate mofetil (an immune-suppressing drug) and steroids. It aims to find which one works better for people with moderate to severe liver inflammation, and may offer a new option for those who cannot take steroids.
This early-phase study is testing a treatment approach for people with alcoholic hepatitis (liver inflammation caused by heavy alcohol use). It may help by improving liver function and outcomes in people who meet specific lab and health criteria.
This study tests whether adding N-acetylcysteine to standard treatment helps people with severe alcoholic hepatitis. It may improve liver outcomes, especially for those with a high Maddrey score.
This trial tests an experimental drug for people with severe alcoholic hepatitis that did not improve with steroids. Participants should have a moderate level of organ failure, but not require a breathing tube or kidney dialysis.
This study tests a new drug called MRG-001 to see if it helps people with alcoholic hepatitis. The trial is looking for patients who have severe alcoholic hepatitis (with jaundice starting in the last 8 weeks) and have been drinking heavily for at least 6 months.
Hear when a new Alcoholic Hepatitis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.