Clin2
NCT07133776Possibly a fitNot yet recruiting

Combination therapy for EBV-related diseases

Epstein-Barr Virus (EBV) InfectionPD-1 InhibitorTenofovirChidamideLenalidomide

Part of Infections clinical trials.

This trial tests a combination of drugs (PD-1 inhibitor, tenofovir, chidamide, and lenalidomide) to treat diseases caused by the Epstein-Barr virus (EBV). The goal is to see if this combination can reduce the virus and improve symptoms.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
30 people
Ages
birth to 75 years
Study type
Interventional

Who can take part

  • You have an EBV-related disease, such as infectious mononucleosis or chronic active EBV infection.
  • Your EBV levels are high (at least 10,000 copies per milliliter of blood).
  • You are 75 years old or younger and are generally able to care for yourself (ECOG score 2 or less).
  • You are expected to live at least 3 more months.
  • You do not have severe liver, kidney, or bone marrow problems, and you have not had recent heart issues or serious infections.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07133763Not yet recruiting· Phase 1/Phase 2
Combination treatment for Epstein-Barr virus-related lymphoma that has returned

This study tests a combination of four drugs (an immunotherapy called a PD-1 inhibitor, an antiviral drug called tenofovir, and two other targeted therapies) for people whose EBV-related lymphoma has come back or not improved after treatment. The goal is to see if this combination can control the disease and help patients live longer.

NCT06666153Not yet recruiting· Phase 1
Immune treatment for EBV-related conditions

This is an early-stage study testing a new immune-based treatment for people with conditions caused by the Epstein-Barr virus (EBV), such as chronic active EBV or post-transplant lymphoproliferative disease. The study aims to see if the treatment is safe and can help control the disease.

Chengdu, Sichuan
NCT07369739Recruiting· Phase 2/Phase 3
Combination therapy for chronic active Epstein-Barr virus disease

This trial tests two drugs, golidocitinib and selinexor, given together to treat chronic active Epstein-Barr virus disease (CAEBVD). The goal is to see if this combination can help control the disease better than current options.

Beijing
NCT07349836Not yet recruiting· Early Phase 1
Mrna immunotherapy for Epstein-Barr virus diseases

This study tests a new mRNA-based immunotherapy for diseases caused by the Epstein-Barr virus (EBV), such as certain cancers and conditions after a stem cell transplant. The treatment aims to help your immune system fight the virus and the disease.

NCT03258567Recruiting· Phase 2
Nivolumab for EBV-related lymphomas and abnormal immune illnesses

This trial tests nivolumab (an immune therapy) for people with EBV-positive lymphoma or EBV-driven immune/lymph conditions. It may help shrink tumors or control the disease when standard treatments have not worked or are not suitable.

Bethesda, Maryland
NCT04664179Recruiting· Phase 1
EBV immune-cell treatment for EBV-positive lymphoma

This Phase 1 study tests an immune-cell therapy made to recognize EBV (a common virus) in people whose lymphoma contains EBV. It may help control EBV-driven cancers, especially when standard treatment isn’t working or can’t be used.

Houston, Texas

Hear when a new Epstein-Barr Virus (EBV) Infection trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.