Drug levels and safety for people with different liver function
Treatments studied
This trial tests how a drug (BMS-986435) behaves in people with normal liver function versus those with liver problems. It also checks that the drug is safe for the heart.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a heart pumping strength (ejection fraction) of 60% or higher on an ultrasound.
- You must weigh at least 50 kg (about 110 pounds) and have a body mass index (BMI) between 18 and 40.
- Your kidneys must work well enough, measured by a blood test showing eGFR over 60.
- You cannot have a history of heart disease, including heart failure, blocked arteries, or damaged heart muscle.
- You cannot have had a head injury in the last 2 years, a brain tumor, or a bulging artery (aneurysm).
- You cannot have had cancer (except for certain skin cancers or cervical cancer treated more than 5 years ago).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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