Lubiprostone for slow-transit constipation in adults
Treatments studied
Part of Digestive system clinical trials.
This study tests whether lubiprostone (Amitiza) can help people with slow-transit constipation. If you have few bowel movements and tests show that stool moves slowly through your colon, this treatment may help you go more regularly.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with chronic functional constipation (Rome IV criteria).
- You have fewer than 3 spontaneous bowel movements per week.
- A colon transit study showed that stool moves slowly through your colon.
- You are at least 18 years old and can use effective birth control if needed.
- You have not taken lubiprostone before and do not have certain other health conditions (like severe depression, thyroid disease, or inflammatory bowel disease).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is for children aged 4–16 who have long-term constipation that doesn't get better with standard laxatives. It uses a test called anorectal manometry to measure how well the muscles in the bottom work, which can help guide treatment.
This study tests whether a probiotic supplement can help relieve constipation in adults. If you have fewer than 3 bowel movements a week or pass hard, lumpy stools, you may be a good fit.
This study tests whether a probiotic product can help adults with constipation have more regular bowel movements. Probiotics are beneficial bacteria that may improve digestive health.
This trial tests a new drug called CMTS4520 for people with long-term constipation. It aims to see if the drug can help you have more bowel movements without needing laxatives or other help. The study lasts for several months and includes regular check-ups.
This study tests whether a probiotic supplement can improve constipation symptoms like infrequent bowel movements or hard stools. It might help you have more regular, softer stools.
This study tests whether a low-FODMAP diet combined with PEG 3350 can reduce symptoms in adults with IBS-C (irritable bowel syndrome with constipation). It may help improve bowel habits and abdominal pain, and it checks which people can safely follow the diet and treatment plan.
Hear when a new Slow Transit Constipation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.