Methotrexate for severe vulvar lichen sclerosus
Treatments studied
Part of Women’s health & pregnancy clinical trials.
This study tests the drug methotrexate as a treatment for severe vulvar lichen sclerosus that has not responded to strong steroid creams. It aims to see if methotrexate can reduce symptoms and prevent further scarring.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have lichen sclerosus on your vulva, perineum, or anal area, confirmed by a skin biopsy.
- Your symptoms have not improved after using a strong corticosteroid cream for at least 3 months.
- You have significant discomfort, with a score over 24 on a quality-of-life questionnaire.
- Your blood tests (including liver, kidney, blood cell counts) are normal, and you are not infected with HIV or hepatitis B/C.
- If you can become pregnant, you have a negative pregnancy test and agree to use effective birth control during the study.
- You must not plan to become pregnant, must avoid heavy alcohol use, and must be able to attend study visits.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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