Comparing two fillers for moderate to severe smile lines
Part of Skin clinical trials.
This study compares a new injection called DIOSHA S Lido to a known filler called YOUTHFILL Fine (both with lidocaine for comfort) to see which works better for treating moderate to severe smile lines. If you join, you'll get one of these treatments to help reduce the appearance of your nasolabial folds.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 19 and 75 years old.
- You have moderate to severe smile lines that are about the same on both sides of your face.
- You are willing to not have other facial treatments (like fillers, Botox, or laser) during the study.
- You do not have any active skin infections, rashes, or untreated scars on your face.
- You have not had any facial cosmetic procedures in the past 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new injectable treatment, DMFI150, for smile lines (nasolabial folds). It aims to see if it can safely reduce their appearance. You may qualify if your smile lines are moderate to severe and you are not taking certain medications.
This study tests a new dermal filler called DXP01 to see if it safely and effectively improves moderate to severe smile lines (nasolabial folds). If you're looking for a non-surgical option to soften those lines, this might be for you.
This study tests a treatment called DMFI300 to reduce the appearance of nasolabial folds (the lines from your nose to the corners of your mouth). It may be an option if you have moderate to deep folds and are willing to avoid other facial treatments during the study.
This trial tests a new filler to treat moderate to severe smile lines (nasolabial folds). It aims to see if it works well for smoothing those lines.
This trial tests a temporary implant made from poly-L-lactic acid (a commonly used material) to smooth moderate to severe smile line wrinkles. Researchers want to see if it works and is safe.
This study tests several hyaluronic acid fillers to improve the look of hollows under the eyes, lips, lines around the mouth, smile lines, and cheeks. It is designed to see how well these fillers work in everyday use.
Hear when a new Nasolabial Folds, Wrinkles trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.