Fecal transplant for primary sclerosing cholangitis study
Treatments studied
Part of Digestive system clinical trials.
This trial tests if a fecal microbiota transplant (FMT) can help people with primary sclerosing cholangitis (PSC) and inactive inflammatory bowel disease (IBD). It compares FMT against a placebo to see if it improves liver health.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have PSC with large bile duct problems, confirmed by specific imaging tests.
- You have IBD that has been inactive for at least 6 months and no changes in your IBD treatment during that time.
- Your liver enzyme ALP is elevated (at least 1.3 times the upper normal limit) or your bilirubin is high with direct bilirubin also high.
- You have been taking ursodeoxycholic acid (UDCA) at a stable dose for at least 3 months and for at least 6 months total.
- You are between 18 and 75 years old and willing to use effective birth control if you are a woman who could become pregnant.
- You agree not to take antibiotics, antifungals, or probiotics 4 weeks before the procedure, and you do not have active infections or cirrhosis.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new treatment called LB-P8 for people with primary sclerosing cholangitis (PSC), a liver disease. It aims to see if LB-P8 is safe and can help slow the disease down. You may join if you meet certain health requirements.
This study tests whether a fecal microbiota transplant (FMT) — transferring healthy stool bacteria into your gut — can help people with severe irritable bowel syndrome (IBS) that hasn't improved after trying at least two other treatments.
This trial tests whether a fecal (stool) transplant from a healthy donor can help people with both PSC and inflammatory bowel disease. It aims to see if the treatment can improve liver health and reduce inflammation. You must have early to moderate liver scarring and be on stable medications.
This study tests whether stool from healthy donors can help people with advanced liver disease (cirrhosis) who have had complications like fluid buildup. You would receive the transplant through a colonoscopy or enema.
This study tests whether a treatment made from mouth bacteria can help people with primary sclerosing cholangitis (PSC). It aims to see if it's safe and improves health.
This trial tests whether fenofibrate can prevent primary sclerosing cholangitis (PSC) from coming back after a liver transplant. It is for adults who had a liver transplant for PSC between 1 and 7 years ago and have certain risk factors.
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