Clinical trials
Wrinkle clinical trials
Below are recruiting wrinkle clinical trials, each written for real people, not researchers. We’re tracking 29 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06831110Recruiting
Hand Wrinkling Study for CF Carriers
This study looks at how quickly hands wrinkle in water for people who are carriers of the cystic fibrosis (CF) gene. The researchers hope to learn if this simple test could help identify CF carriers, and your participation could help answer that question.
Iowa City, IowaAges 18–24 - NCT03793348Recruiting
Micro-coring device to improve moderate to severe facial wrinkles
This study tests a device that removes tiny skin cores (“micro-coring”) to improve moderate to severe wrinkles on the face, especially the cheeks. It mainly checks safety and whether skin texture looks better after treatment.
Sacramento, CaliforniaAges 40–70 - NCT07551609Recruiting
Hyaluronic Acid Injection Study for Facial Wrinkles
This study tests RRS® HA Long Lasting, an injectable treatment designed to smooth moderate to severe facial wrinkles and improve overall skin quality. If you qualify, you'll receive injections and be monitored over time to see how well the treatment works.
Barcelona, BarcelonaAges 18 years+ - NCT07331181Recruiting
Studying a treatment for cheek and décolletage wrinkles
This trial tests two treatments called INNEA and INNEA AQUA for cheek and décolletage wrinkles. The goal is to see how well they work and if they are safe for women aged 35-65.
Brescia, BresciaAges 35–65 - NCT07255261Recruiting
Study of facial fillers for wrinkles and volume loss
This study tests several hyaluronic acid fillers to improve the look of hollows under the eyes, lips, lines around the mouth, smile lines, and cheeks. It is designed to see how well these fillers work in everyday use.
ArrasAges 18 years+ - NCT07225348RecruitingPhase 4
Treating mouth wrinkles with microneedling and a topical gel
This study tests a treatment for wrinkles around the mouth using a special gel (poly-L-lactic acid) applied with a microneedling device. It may help reduce wrinkles without surgery.
Chestnut Hill, MassachusettsAges 40–70 - NCT07222397Recruiting
Laser treatment for deep wrinkles around the mouth
This study tests a special laser to treat deep lines and wrinkles around the mouth. It may help if you are between 50 and 80 years old and have fair to light brown skin.
Houston, TexasAges 50–80 - NCT06854796Enrolling by invitation
Collagen gel for nose-to-mouth lines
This trial is testing a new collagen gel to reduce moderate to deep nose-to-mouth lines. It compares the gel to a control (no active treatment) to see if it works better and is safe.
BeijingAges 18–65 - NCT07871708Recruiting
Beauty device for skin concerns
This study tests a handheld beauty device that may improve wrinkles, skin firmness, and skin texture. If you have signs of aging or skin texture issues, you might be eligible to try it at no cost.
Baltimore, MarylandAges 30–65 - NCT07779252RecruitingPhase 3
Study of a new treatment for frown lines between the eyebrows
This study tests a new medication (IPN10200) to safely reduce moderate to severe frown lines between the eyebrows in adults. It may help if you are bothered by these lines and are looking for a non-surgical option.
Guangzhou, GuangdongAges 18 years+ - NCT07774000Recruiting
Cream for reducing facial wrinkles and other signs of aging
This study tests a cream containing a special form of vitamin B3 (called niacinamide riboside) to see if it can help reduce wrinkles, fine lines, and other signs of aging on the face. It might help your skin look smoother and more radiant.
Cape Town, Western CapeAges 30–60 - NCT07664280Recruiting
Facial acupuncture for skin aging
This study tests whether a single session of facial acupuncture can improve your skin's structure and how satisfied you are with your appearance. If you are concerned about facial aging and are in good general health, you may be able to join.
TaipeiAges 30–60 - NCT07545980Recruiting
CelluJuve for moderate to severe forehead wrinkles
This study tests CelluJuve®, an injectable filler, to smooth moderate to severe forehead wrinkles (called nasolabial folds). The goal is to see if it safely improves wrinkle appearance over time.
Coral Gables, FloridaAges 22 years+ - NCT07495865Recruiting
Safety and performance study of AnGelHA 2 dermal filler
This study is checking how safe and effective AnGelHA 2, a dermal filler, is. It's for people who want treatment for wrinkles or adding volume to their face.
Lod, IsraelAges 18 years+ - NCT07467239Recruiting
Study of DMFI300 for nasolabial folds
This study tests a treatment called DMFI300 to reduce the appearance of nasolabial folds (the lines from your nose to the corners of your mouth). It may be an option if you have moderate to deep folds and are willing to avoid other facial treatments during the study.
MarbellaAges 18–70 - NCT07398768Recruiting
Study on a procedure for lines around the mouth and thin lips
This study is looking at a treatment for wrinkles around the mouth and to make the lips fuller. It's for people who already plan to get this treatment at their doctor's office.
Vienna, State of ViennaAges 18 years+ - NCT07342400Recruiting
Study on cheek wrinkles treatment in women at different menopause stages
This study tests a treatment called poly L-lactic acid for cheek wrinkles and volume loss in women. It compares how well the treatment works depending on a woman's menopause stage by looking at skin changes under a microscope.
Miami, FloridaAges 22 years+ - NCT07292779Recruiting
Testing a new filler for smile lines
This study tests a new injectable treatment, DMFI150, for smile lines (nasolabial folds). It aims to see if it can safely reduce their appearance. You may qualify if your smile lines are moderate to severe and you are not taking certain medications.
MarbellaAges 18–70 - NCT07187297Recruiting
Radiofrequency skin tightening study for loose skin and wrinkles
This study tests a radiofrequency device called Thermage® FLX to see how well it tightens skin and reduces wrinkles on the neck, face, belly, or upper arms. It may be a good option if you have mild to moderate skin looseness or lines and haven't had recent cosmetic procedures.
Sacramento, CaliforniaAges 30–60 - NCT07188051Enrolling by invitation
Beauty from within hair, nail and skin trial
This trial tests a daily supplement to see if it helps improve facial wrinkles, sagging skin, hair growth, thickness, and nail strength. It could help people who are concerned about these signs of aging and want a natural approach.
Cincinnati, OhioAges 35–65 - NCT07178119Recruiting
Bridging technique for nasolabial folds study
This study tests a specific 'bridging' technique for filling deep smile lines (nasolabial folds) using a hyaluronic acid filler. Researchers want to see if this method is safe and effective for reducing the appearance of these lines.
Warrington, CheshireAges 30–65 - NCT06333067Recruiting
Ultrasound treatment for lifting sagging skin and wrinkles
This study tests a new ultrasound device to lift sagging facial skin and reduce wrinkles. It is for people who want a non-surgical option to tighten their face and neck.
La Mesa, CaliforniaAges 35–80 - NCT04818203RecruitingPhase 1/Phase 2
Autologous fibroblast injections for crow’s feet wrinkles
This study tests a safety and effectiveness approach for reducing crow’s feet (wrinkles at the outer corners of the eyes) using cells made from your own skin. You may be asked to stop other wrinkle treatments and have blood tests and injections at a specific skin area.
SeoulAges 19 years+ - NCT07028203Enrolling by invitation
Non-invasive eye area rejuvenation for aging signs
This trial tests a non-invasive treatment to improve under-eye bags and wrinkles around the eyes. It may help people who want to refresh their eye area without surgery.
Sacramento, CaliforniaAges 21 years+
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Wrinkle trials by city
Studies with a site in or near these metro areas.
Wrinkle trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for wrinkle?
- Yes. Clin2 currently lists 29 recruiting wrinkle studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a wrinkle trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a wrinkle trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.