Clinical trials
Postoperative Pain clinical trials
Below are recruiting postoperative pain clinical trials, each written for real people, not researchers. We’re tracking 564 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07341854Recruiting
Dexamethasone shot for pain after surgery
This study tests a special form of dexamethasone (a steroid) given as a shot before surgery to help control pain after the operation. It may reduce the need for other pain medicines and make recovery more comfortable.
Beijing, ChinaAges 18–65 - NCT06878014RecruitingPhase 4
Morphine for pain relief after hip replacement surgery
This trial tests different doses of morphine given during spinal anesthesia to find the safest and most effective way to control pain after hip replacement surgery. If you are having a total hip replacement, you may be able to join.
Sosnowiec, Silesian VoivodeshipAges 18–75 - NCT06696430Recruiting
Nudging to use TENS for pain after surgery
This trial tests whether a simple reminder (nudging) can encourage staff and patients to use a device called TENS, which uses mild electrical pulses to help reduce pain after urological surgery.
Gothenburg, VGRAges 18 years+ - NCT07642596Recruiting
Root Canal Treatment Methods and Post-Procedure Pain
This study compares two different techniques for cleaning and shaping root canals (the nerve chambers inside teeth) to see which one causes less pain after treatment. If you have a dead nerve in a back lower tooth, this trial may help us understand the best way to treat it with minimal discomfort.
Eskişehir, OdunpazarıAges 18–65 - NCT03489499Recruiting
Genetic testing study of pain after planned surgery
This study looks at whether genetic differences can help predict how much pain you may have after an elective (planned) operation. If you qualify, you may be asked to give consent and share information so researchers can compare pain experiences across people.
BernAges 18 years+ - NCT05172739RecruitingPhase 4
Opioid-free anesthesia during lung surgery for early lung cancer
This study tests whether an opioid-free pain/anesthesia plan during elective lung surgery can reduce surgical “stress” on the body and affect the immune system. You may be eligible if you have early-stage non-small cell lung cancer and are scheduled for a specific type of surgery (VATS lobectomy).
Heraklion, CreteAges 18–80 - NCT05193227RecruitingPhase 2
Slow-release lidocaine patch for pain after pelvic surgery
This Phase 2 study tests a slow-release form of lidocaine to reduce pain after surgery that uses a pelvic incision. If you’re having a qualifying pelvic operation, the study may help see whether this medication improves postoperative pain control.
Vancouver, British ColumbiaAges 19 years+ - NCT05917262Recruiting
Mindfulness breathing vs heart-rate training after shoulder surgery pain
This trial compares two non-drug techniques—mindful breathing and heart-rate (HR) biofeedback—to see which helps reduce pain after shoulder surgery. You may be able to join if you have ongoing shoulder pain after surgery and haven’t been using these practices very often.
TaoyuanAges 18 years+ - NCT06023225Recruiting
Sex hormones, pain, and opioid use in girls after surgery
This study looks at how sex hormones affect pain and the use of pain medicine after orthopedic surgery in girls. It might help explain why some people need more pain relief than others.
St Louis, MissouriAges 11–16 - NCT06379425RecruitingPhase 4
Can pain meds without opioids help you pee sooner after surgery?
This study looks at whether giving a mix of pain medicines (without opioids) before surgery can help you recover faster and avoid needing a catheter after a vaginal repair or sling procedure. It enrolls women having minor gynecologic surgery at the South Shore Surgery Center in New York.
Bay Shore, New YorkAges Any age - NCT07694141Recruiting
Pain Relief After Chest Surgery
This trial studies how well different pain medications work after thoracic (chest) surgery. It aims to find the best way to manage pain and improve recovery.
Las Palmas de Gran Canaria, Las PalmasAges 18 years+ - NCT04908579RecruitingPhase 4
Preventive ketamine to reduce pain after surgery
This study tests whether giving ketamine before or during surgery can reduce pain afterward. It is designed for adults with higher body weight who also have certain health conditions like well-controlled diabetes or blood pressure.
CairoAges 21–60 - NCT06803732Recruiting
Pain after robotic, endoscopic or open neck surgery for thyroid cancer
This trial compares pain levels after three different surgical methods for removing cancerous lymph nodes in the neck. It may help patients with thyroid cancer that has spread to neck lymph nodes understand which approach causes less discomfort.
Shanghai, Shanghai MunicipalityAges Any age - NCT06936995Recruiting
Comparing pain relief methods for ACL surgery recovery
This trial tests two ways to manage pain after ACL reconstruction: a combination of medications (multimodal analgesia) versus a nerve block in the thigh (femoral block). The goal is to see which approach provides better pain control and recovery.
AnkaraAges 18–65 - NCT07073846RecruitingPhase 4
Lidocaine and dexmedetomidine for pain after weight-loss surgery
This study tests whether adding two medicines (lidocaine and dexmedetomidine) to your anesthesia during weight-loss surgery can reduce pain, swelling, and stress on the body. It might help you have a smoother recovery.
Mexico City, Mexico CityAges 18–60 - NCT07308730Recruiting
Pain diary after gallbladder surgery
This study looks at whether using a pain diary can help people manage pain better after gallbladder removal surgery. If you are having this surgery for the first time and can read and write in Turkish, you may be able to join.
Muğla, MenteşeAges 18 years+ - NCT07336264Recruiting
Understanding acute pain in children
This study looks at how children and teens experience pain after surgery or during a bone marrow transplant. It aims to better understand acute pain, which is short-term pain that goes away as the body heals.
Washington D.C., District of ColumbiaAges 6–21 - NCT07472296Recruiting
Comparing nerve blocks for heart surgery pain relief
This trial compares different types of nerve blocks to see which works best for managing pain after heart surgery through the breastbone. It may help reduce the need for strong pain medications.
Bursa, NilüferAges 18–80 - NCT07604376Recruiting
Nerve Block Pain Relief After Cesarean Delivery
This study tests whether a nerve-numbing injection in the abdomen helps reduce pain after a cesarean (C-section) delivery. The injection uses a local anesthetic to numb the area around your surgical wound, potentially reducing pain and the need for stronger pain medicines after surgery.
Târgu Mureş, Mureș CountyAges 18 years+ - NCT07633444Recruiting
Ear Stimulation to Reduce Pain After Abdominal Surgery
This study tests whether mild electrical stimulation applied to your ear can reduce pain and the need for pain medication after abdominal or urologic surgery. Researchers will try different stimulation frequencies to find what works best.
Salvador, Estado de BahiaAges 18–59 - NCT07242872Enrolling by invitation
Screen addiction and pain after nose surgery
This trial looks at whether screen addiction affects pain levels after rhinoplasty (nose job). It will help doctors understand if screen habits influence recovery.
Tokat Province, Tokat ProvinceAges 18–45 - NCT06865378Enrolling by invitation
Breathing gas and nausea after hysterectomy study
This study looks at whether levels of carbon dioxide in your breath and blood flow measurements during surgery can help predict nausea, vomiting, or pain after a hysterectomy. It may help doctors better manage your recovery.
IstanbulAges 20–65 - NCT07706348RecruitingPhase 1/Phase 2
Pain relief with ondansetron and lidocaine after abdominal cancer surgery
This trial tests if rinsing the belly with ondansetron (a nausea medicine) and lidocaine (a numbing medicine) during surgery can reduce pain afterward. It is for people having major lower abdominal cancer surgery who are otherwise healthy.
AsyutAges 20–70 - NCT05010148RecruitingPhase 3
IV lidocaine after spinal fusion to reduce delirium and pain
This trial tests whether giving lidocaine through a vein after elective spinal fusion surgery can help prevent confusion (delirium) and reduce pain. It may help people recover more comfortably and think more clearly after surgery.
San Francisco, CaliforniaAges 60 years+
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Postoperative Pain trials by city
Studies with a site in or near these metro areas.
Postoperative Pain trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for postoperative pain?
- Yes. Clin2 currently lists 564 recruiting postoperative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a postoperative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a postoperative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Postoperative Pain, Acute
- Postoperative Pain Management
- Chronic Postoperative Pain
- Total Knee Arthroplasty (Postoperative Pain)
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
- Postoperative Pain After Endodontic Treatment
- Postoperative Pain Following Knee Arthroplasty
- Postoperative Pain Management in Oral Surgery
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.