Study of rare immune system genetic disorders
Part of Genetic & congenital, Immune system & allergy clinical trials.
This study looks for genetic causes of immune problems, such as unusually frequent infections, abnormal allergies, or autoimmune or inflammation conditions. It may help by improving how doctors understand these disorders and by matching families with possible genetic diagnoses.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You (or the patient) are between ages 0 and 99, including pregnant or breastfeeding people
- You have a known genetic cause of an immune disorder or symptoms that suggest a serious immune problem
- A doctor outside NIH must provide a letter or clinical summary of your medical history
- You agree to donate blood, saliva, and tissue samples for future research
- You agree to genetic testing and allow sharing results in secure research databases
- You likely do NOT have a well-known, already fully studied immune disorder like SCID or CGD
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study aims to better understand primary immune disorders by collecting genetic and blood (and related) information. It may help researchers identify what causes these conditions and improve future testing and care.
This study screens people who may have an inherited immune system condition (like problems with immune cell growth or death) and their blood relatives. The goal is to understand the condition better by collecting blood samples for testing.
This research looks at how inherited (genetic) changes may affect the immune system in people with immune problems. It may help by improving understanding of these conditions and, in some cases, guiding faster care for a baby after birth.
This study collects and sequences (reads) your DNA to help researchers understand health and disease. You may be invited because you are connected to another NIH study, and you must agree to testing, sample storage, and sharing de-identified genetic data for future research.
This study looks at how the immune system works in people who have—or might have—an increased risk of infections. It also enrolls their healthy blood relatives so researchers can compare immune features; results may help doctors understand who is at higher risk and why.
This study follows people with rare “autoinflammatory” conditions and sometimes their blood relatives to understand why symptoms happen and how they change over time. It may help by improving diagnosis and care for these conditions, using stored samples and genetic testing.
Hear when a new CTLA4 trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.