Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,055 recruiting studies in this area right now.
By phase
- Not applicable3,000
- Phase 21,059
- Phase 1791
- Phase 3437
- Phase 1/Phase 2436
- Phase 4234
- Phase 2/Phase 398
Top conditions
- Multiple Sclerosis330
- Multiple Myeloma327
- Asthma193
- Lymphoma178
- Rheumatoid Arthritis132
- Type 1 Diabetes130
- Atopic Dermatitis127
- Systemic Lupus Erythematosus120
- Acute Lymphoblastic Leukemia118
- HIV Infections106
- Chronic Lymphocytic Leukemia96
- Autoimmune Diseases77
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)67
- Diabetes Mellitus, Type 163
- Hodgkin Lymphoma63
- Leukemia63
- Mantle Cell Lymphoma62
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca63
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- Mayo Clinic49
- City of Hope Medical Center47
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California495
- Maryland200
- Alabama179
- Florida148
- Arizona147
- Massachusetts116
- New York116
- Texas112
- Illinois83
- Colorado82
Recruiting studies6,055 total
- NCT06430736RecruitingPhase 2
Tocilizumab before or during CAR-T therapy
This study tests whether giving tocilizumab (a drug that calms inflammation) before CAR-T cell therapy helps prevent side effects. It compares using it ahead of time versus only when needed. You may be eligible if you are scheduled for CAR-T therapy for lymphoma, leukemia, or myeloma.
Bern, Canton of BernAges 18 years+ - NCT07200102RecruitingPhase 1
Selinexor after CAR-T for high-risk multiple myeloma
This study tests whether taking selinexor after CAR-T cell therapy can help keep multiple myeloma from coming back. It is for people whose myeloma is high-risk or still has signs of disease after CAR-T.
St Louis, MissouriAges 18 years+ - NCT07109219RecruitingPhase 1/Phase 2
Study of AZD4512 alone or with other drugs for leukemia
This study tests a new medicine called AZD4512, given alone or with other cancer drugs, for people whose B-cell acute lymphoblastic leukemia (a type of blood cancer) has come back or not improved after treatment. The goal is to see if it can help control the disease.
Duarte, CaliforniaAges 12 years+ - NCT05735704Recruiting
Blood cancer early detection study
This study looks for early signs of blood cancers in people who have them or are at higher risk, like family members or older adults. It aims to find cancer sooner, which may lead to better outcomes.
OlomoucAges 18 years+ - NCT06463886Recruiting
HIV medication support for Black women who have experienced trauma
This study tests a program to help Black women living with HIV take their HIV medication regularly, especially if they have had trouble staying on treatment or missed doctor visits. The program aims to empower women and improve their health.
Miami, FloridaAges 18 years+ - NCT07387926RecruitingPhase 1/Phase 2
Testing asciminib for children and young adults with a type of leukemia
This trial tests an experimental drug called asciminib for children and young adults whose leukemia (a specific type of B-cell acute lymphoblastic leukemia with certain gene changes) has come back or not responded to treatment. The goal is to see if the drug is safe and effective for these patients.
Sydney, New South WalesAges 1–30 - NCT06948110Recruiting
Searching for genes linked to autoimmune diseases
This study looks for genes that may be linked to autoimmune diseases by comparing the DNA of people with these conditions to healthy family members or volunteers. If you have an autoimmune disease or are a healthy person interested in helping research, this study may help scientists understand why these diseases run in families.
Bethesda, MarylandAges 18–115 - NCT07453004RecruitingPhase 2
Study of plonmarlimab for frequent gout attacks
This trial tests a new investigational drug called plonmarlimab for people with frequent, painful gout flares who cannot take standard treatments. The goal is to see if it can reduce pain and inflammation from the flare.
Bengbu, AnhuiAges 18 years+ - NCT07731789RecruitingPhase 2
Antibody combo for newly diagnosed follicular lymphoma
This trial tests two antibody medications, tafasitamab and rituximab, as the first treatment for newly diagnosed follicular lymphoma. The goal is to see if this combination can effectively control the lymphoma and potentially reduce the need for more intensive therapies.
Seattle, WashingtonAges 18 years+ - NCT03394053Recruiting
Studying the causes of primary immunodeficiency disorders
This study looks at blood samples and genetic information from people with primary immunodeficiency (a condition where the immune system doesn't work properly), their relatives, and healthy volunteers. The goal is to learn more about what causes these disorders, which could help improve future treatments.
Washington D.C., District of ColumbiaAges 1 day–90 years - NCT07275580RecruitingPhase 4
Antibiotics before tooth removal for people with immune disorders
This trial tests whether taking preventive antibiotics before a simple tooth extraction helps prevent infections in people with weakened immune systems due to autoimmune diseases. It might help you avoid complications after your dental procedure.
São Paulo, São PauloAges 18 years+ - NCT06664814RecruitingPhase 2
Study of ManNAc for kidney diseases with proteinuria
This study tests a new drug called ManNAc for people with certain kidney diseases (FSGS, MCD, or MN) that cause protein in the urine. The goal is to see if this drug can help reduce protein loss and improve kidney health.
Bethesda, MarylandAges 18–115 - NCT07557056RecruitingPhase 2
Oral combination treatment for untreated chronic lymphocytic leukemia
This clinical trial tests two oral medications, nemtabrutinib and venetoclax, given together to people with untreated CLL or SLL. The goal is to see if this combination effectively kills cancer cells and helps you stay in remission with manageable side effects.
Columbus, OhioAges 18 years+ - NCT05633615RecruitingPhase 2
Testing new drug options after CAR T for aggressive lymphoma
This Phase 2 study tests whether adding or switching drug treatments after CAR T-cell therapy can improve outcomes for people with certain aggressive lymphomas that have come back or did not respond. It mainly looks at who remains disease-stable/partly improved after CAR T and what treatment approach works best next.
Tucson, ArizonaAges 18 years+ - NCT07818031Recruiting
Comparing two types of in-office teeth whitening
This study compares two types of in-office teeth whitening treatments – one with peroxide and one without – to see which works better for brightening your smile. If you're looking to whiten your teeth, this trial may help you achieve a whiter shade safely.
Minya, Minya GovernorateAges 18–45 - NCT07262983RecruitingPhase 1
Baricitinib for Job syndrome with lupus or eczema
This study tests if baricitinib, a pill that changes how your immune system works, is safe and tolerable for people with Job syndrome who also have lupus-like disease or severe eczema. It might offer a new treatment option for these skin and immune problems.
Bethesda, MarylandAges 12–120 - NCT07253883Recruiting
New breathing device test for asthma and COPD
This trial is testing a new breathing device that may be as accurate as standard tests for diagnosing asthma and COPD. It could offer a simpler and quicker way to check your lung health.
Liverpool, MerseysideAges 18–110 - NCT03746769RecruitingPhase 1/Phase 2
Testing gastrin to improve results of islet cell transplant
This trial looks at whether adding gastrin can improve outcomes after an islet cell transplant for people with type 1 diabetes. It may help some participants achieve better blood sugar control, but it also requires close follow-up and immune-suppressing medications to protect the new cells.
Duarte, CaliforniaAges 18–68 - NCT06904066RecruitingPhase 1
Personalized T cell therapy for blood cancers
This trial tests a treatment that takes your own immune cells, modifies them to attack cancer cells, and gives them back to you. It is for people with certain blood cancers who have specific gene changes.
Bethesda, MarylandAges 18–120 - NCT07867184Enrolling by invitation
Firefighter lung health study
This study looks at how firefighting affects your lungs over time. By tracking your health and exposures, researchers hope to find ways to prevent lung problems in firefighters.
Bethesda, MarylandAges 18–65 - NCT07386743RecruitingPhase 3
New injection for moderate-to-severe eczema
This study tests a new injection called GS101 compared to an existing treatment (Dupixent) for people with moderate-to-severe atopic dermatitis (eczema). If you join, you may receive either the new drug or the standard treatment, and researchers will track how well it controls your symptoms.
Shenyang, LiaoningAges 18–75 - NCT07754786RecruitingPhase 3
Comparing a new eczema medicine with dupilumab
This study tests whether a new biologic medicine (IBI3027) works as well as an approved medicine (dupilumab) for treating moderate-to-severe eczema. If you join, you may receive one of the two treatments, and researchers will compare their effects on your skin and itching.
Guangzhou, GuangdongAges 18–75 - NCT05776927RecruitingPhase 3
Testing a new inhaler for teens with asthma
This trial tests a new combination inhaler (QVM149) against a standard one (Advair) in teenagers with asthma that isn't well controlled by their current medicine. It aims to see if the new inhaler works better.
Rosario, Santa Fe ProvinceAges 12–17 - NCT07612475Enrolling by invitation
Universal type 1 diabetes screening in children
This study helps clinics add a simple blood test to well-child visits to catch type 1 diabetes early, before symptoms appear. It also asks parents and clinic staff for feedback to make screening easier and more routine.
Alexander City, AlabamaAges 1 year+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,055 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,051 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.