Pre-surgery nivolumab for certain types of breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests whether giving nivolumab before surgery (neoadjuvant treatment) can improve outcomes for people with certain resectable breast cancers. It focuses on tumor types linked to immune activity (like triple-negative and specific lab markers).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You can take part only if you’re able to sign consent and are 18 or older
- You must be female and have good general health (WHO performance status 0 or 1)
- Your breast cancer must be stage I to III and still operable (resectable)
- Your tumor must be at least 10 mm on MRI, and lab testing must fit a specific subtype (often HER2-negative with certain ER, Ki-67, PR, or grade patterns)
- Your tests must show certain immune-cell levels inside the tumor (TILs), which depend on your subtype and which study group you match
- You must not have metastatic cancer, a second breast cancer in the same or opposite breast, or have had chemotherapy/radiation/checkpoint immunotherapy before
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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