Preventing CMV after a haploidentical stem cell transplant
Part of Immune system & allergy, Infections clinical trials.
This Phase 2 study tests a preventive “cell therapy” made from a donor’s immune cells to lower the risk of CMV infection after a haploidentical stem cell transplant. If you’re at risk for CMV, this may help protect you during the early post-transplant period.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult who had a haploidentical (half-matched) stem cell transplant from a donor
- The donor must test positive for CMV, and the donor must not have an active infection around the cell collection time
- Your blood counts must be starting to recover after transplant (neutrophils above a certain level for at least 3 check times)
- You cannot be on steroid medicines at the time of the planned cell infusion (for example, about 0.5 mg/kg/day prednisone or equivalent)
- You must not have serious ongoing illness issues: very poor activity level, severe organ side effects, uncontrolled or unresolved infection, or persistent fevers just before infusion
- You must not have moderate-to-severe graft-versus-host disease (GVHD), a relapse before infusion, or a new CMV infection/reactivation before infusion
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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