Study of GBA changes in Parkinson’s using multiple tests
Part of Brain & nervous system, Genetic & congenital, Hormones & metabolism clinical trials.
This study looks at people with Parkinson’s who carry a specific genetic change in the GBA gene. It uses several tests (including brain scans) to understand the disease better and may help guide future treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re between 18 and 80 years old.
- Your genetic test shows a harmful (pathogenic) GBA change, or a known GBA variant.
- You do not have another neurological disorder along with Parkinson’s.
- You can safely have MRI brain scans (no incompatible implants or metal devices).
- You do not have severe claustrophobia (strong fear of being in a small space).
- You can tolerate stopping certain Parkinson’s medicines if you are asked to (if you have GBA-PD).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at non-motor symptoms (like mood, thinking, or sleep problems) in people with a specific genetic change linked to Parkinson's disease. It compares those with the GBA gene change to those without it to see how symptoms differ.
This registry collects information about people with Parkinson’s who have specific changes in the GBA gene. The goal is to better understand how these gene changes affect Parkinson’s and support future research.
This study is looking for ways to find new drugs that may help people with Parkinson’s caused by changes in the GBA gene. It may also include people with Gaucher disease and healthy volunteers, using blood and possibly skin samples.
This trial tests an investigational drug called GT-02287 in people with early-stage Parkinson's disease (diagnosed within the last 7 years). The goal is to see if it is safe and how the body processes it, with a special focus on people with certain genetic changes (GBA1 mutations) that may be linked to Parkinson's.
This study aims to understand genetic factors in lysosomal storage disorders—rare conditions where the body cannot break down certain substances. Researchers will collect information from patients with these disorders, their family members, and healthy volunteers to learn how these diseases develop and affect people over time.
This study looks at how standard treatments for Gaucher disease affect lung problems, bone damage, and parkinson-like symptoms. It aims to find better ways to treat these complications and improve quality of life.
Hear when a new GBA Gene Mutation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.