Carboplatin and paclitaxel before surgery for vulvar cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests giving chemotherapy (carboplatin and paclitaxel) before surgery for certain cases of squamous cell vulvar cancer. It may help shrink the tumor and make surgery more effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a woman age 18 or older
- Your vulvar cancer biopsy showed squamous cell vulvar cancer (not a different type)
- Your cancer can be measured on exam and fits stage T2 with no distant spread
- You can do usual daily activities fairly well (performance status 0 to 2)
- Your blood, liver, and kidney tests are adequate
- You have not had radiation to the vulva, groins, or pelvis
- You are not pregnant (and if you could become pregnant, you have a negative pregnancy test)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies how well carboplatin plus paclitaxel chemotherapy works for vulvar squamous cell cancer that has spread. It may help shrink tumors and control cancer growth in people who are not able to be fully treated with local surgery.
This Phase 2 trial compares two treatment approaches for some women with vulvar squamous cell cancer: chemoradiation first, or chemotherapy first followed by surgery. The goal is to see which strategy works better or is safer for tumors that are hard to remove without major pelvic surgery.
This study tests whether combining two immunotherapy drugs—nivolumab (given by IV) and imiquimod (a cream)—is safe and works in people with vulvar cancer that is hard to treat. The goal is to shrink the tumor before surgery, making it easier to remove.
This trial is for people with early-stage vulvar cancer that can be surgically removed. It looks at the cancer's HPV and p53 status to decide how much tissue to remove, aiming to reduce side effects while keeping the cancer away.
This trial tests an oral form of a common chemo drug, paclitaxel, given before surgery for triple-negative breast cancer. It aims to find the best dose and see how well it shrinks tumors.
This trial tests giving a combination of an immunotherapy drug (QL1706) and two chemotherapy drugs (cisplatin and paclitaxel) before surgery for cervical cancer. The goal is to shrink the tumor to make surgery more effective and improve outcomes.
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