Vulvar cancer treatment: chemoradiation vs chemotherapy then surgery
Treatments studied
Part of Cancer clinical trials.
This Phase 2 trial compares two treatment approaches for some women with vulvar squamous cell cancer: chemoradiation first, or chemotherapy first followed by surgery. The goal is to see which strategy works better or is safer for tumors that are hard to remove without major pelvic surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a woman age 18 or older and can sign consent
- You have vulvar squamous cell cancer that is primary or has come back, stage IB to IVA (no distant spread to other organs)
- Your tumor location/size means you would usually need either chemoradiation, or a major surgery that risks pelvic organ damage or removes multiple areas (exenteration)
- You can do daily activities at a good level (performance status 0–2)
- Your blood, liver, and kidney tests are strong enough for treatment
- You have no prior radiation to the pelvis or groin that would limit full-dose chemoradiation
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests giving chemotherapy (carboplatin and paclitaxel) before surgery for certain cases of squamous cell vulvar cancer. It may help shrink the tumor and make surgery more effective.
This trial studies how well carboplatin plus paclitaxel chemotherapy works for vulvar squamous cell cancer that has spread. It may help shrink tumors and control cancer growth in people who are not able to be fully treated with local surgery.
This study tests whether combining two immunotherapy drugs—nivolumab (given by IV) and imiquimod (a cream)—is safe and works in people with vulvar cancer that is hard to treat. The goal is to shrink the tumor before surgery, making it easier to remove.
This Phase 2 study looks at how vulvar squamous cell cancer (SCC) spreads to the sentinel lymph node, and how findings may guide treatment. It focuses on specific early-stage tumor features and requires that cancer is found in the sentinel lymph node.
This trial is for people with early-stage vulvar cancer that can be surgically removed. It looks at the cancer's HPV and p53 status to decide how much tissue to remove, aiming to reduce side effects while keeping the cancer away.
This Phase 1 trial tests whether adding nelfinavir to standard chemo (cisplatin) and external-beam radiation can treat locally advanced vulvar cancer that cannot be removed with surgery. It’s designed to check safety and how well the treatment can work for this situation.
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