Lowering biologic doses for Crohn’s and ulcerative colitis
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether people with Crohn’s disease or ulcerative colitis who are currently well-controlled can safely use less-frequent anti-TNF medicine. It may help reduce treatment intensity while keeping inflammation under control.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Ages 12 to 25 years
- Have Crohn’s disease (non-perianal) or ulcerative colitis
- Currently taking infliximab every 8 weeks or adalimumab every 2 weeks as their first anti-TNF, or a prior anti-TNF was stopped for reasons other than not working or later wearing off
- Have evidence of low gut inflammation recently (stool test calprotectin in the target range for the last 6 months, or recent endoscopy showing remission)
- Do not have active bowel symptoms right now, based on your IBD team’s judgment
- Not on steroid medicines (prednisone or budesonide) and not pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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