Clin2
NCT04850729Possibly a fitRecruiting

Study links surgery medicines to the stomach tumor environment

Gastric AdenocarcinomaGastroesophageal Junction Adenocarcinoma

Part of Cancer, Digestive system clinical trials.

This trial looks at how medicines given around the time of stomach cancer surgery may change the “tumor microenvironment,” which is the biology around the tumor. It may help doctors better understand which perioperative treatments work best for locally advanced, operable stomach cancer.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
169 people
Ages
18 years to 75 years
Study type
Observational

Who can take part

  • You have confirmed locally advanced stomach (or stomach–esophagus junction) adenocarcinoma that can be surgically removed, with no distant metastases
  • You’re 18 to 75 years old
  • You can provide leftover tumor tissue after your usual diagnosis for special tumor-environment testing
  • You plan to receive medicines during the perioperative (around-surgery) period
  • Your overall health/activity level is ECOG 0 or 1 (generally fully active or limited but ambulatory)

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07603349Not yet recruiting· Phase 2/Phase 3
Personalized follow-up treatment after surgery for stomach cancer

This trial is looking at whether giving extra treatment after surgery for stomach cancer can help lower the chance of it coming back. It is for people who had a specific kind of chemotherapy and immunotherapy before surgery and then had their stomach removed.

Guangzhou, Guangdong
NCT06155383Recruiting· Phase 2
Surgery and immunotherapy combo for stomach cancer

This trial tests a combination of three drugs (Disitamab Vedotin, Toripalimab, and XELOX) given before and after surgery for gastric or gastroesophageal junction cancer. The goal is to see if this treatment helps shrink the tumor and prevent it from coming back.

Beijing, Beijing Municipality
NCT07692477Not yet recruiting
Studying tumor tissue to predict drug resistance in stomach cancer

This study looks at tissue samples from stomach or gastroesophageal junction cancer to understand how the tumor interacts with its surroundings, which may help predict if the cancer will resist treatment. All participants will receive standard chemotherapy (FLOT) plus durvalumab before and after surgery.

NCT07178808Recruiting· Phase 2
Surgery and heated chemotherapy for stomach cancer

This trial tests if surgery to remove visible cancer in the belly combined with heated chemotherapy placed directly into the abdomen can help people with stomach cancer that has spread to the lining of the belly. It is for patients who are well enough to undergo major surgery and meet specific health requirements.

Gilbert, Arizona
NCT07643623Recruiting· Phase 2/Phase 3
Immunotherapy for operable stomach cancer before and after surgery

This trial tests a combination of immunotherapy drugs (sintilimab, chemotherapy, and sometimes ipilimumab) given before surgery to shrink stomach or esophageal junction tumors, then continued after surgery. The goal is to improve survival in patients with resectable (removable) gastric or gastroesophageal junction cancer.

Guangzhou, Guangdong
NCT06766578Recruiting· Phase 2
Low-dose radiation plus immunotherapy and chemo before gastric cancer surgery

This trial tests a new combination of low-dose radiation, an immunotherapy drug (tirelizumab), and chemotherapy (SOX) given before surgery for locally advanced gastric or gastroesophageal junction cancer. The goal is to see if this approach can shrink tumors more effectively.

Jinan, Shandong

Hear when a new Gastric Adenocarcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.