Givastomig for advanced solid cancers, including gastric and pancreas
Part of Cancer, Digestive system clinical trials.
This Phase 1 trial tests how safe and effective givastomig (TJ033721) is for advanced or metastatic solid tumors. It may help people whose cancer has grown despite standard treatment, or—if in the combination parts—specific cancers that meet certain lab test and tumor-marker requirements.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your cancer is advanced or has spread, and it has either progressed on standard treatment or you have no standard option
- You must have an Eastern Cooperative Oncology Group (ECOG) score of 0 or 1 (you can do most daily activities) and have blood/organ tests that look adequate
- You must have a known PD-L1 test result from prior immunohistochemistry testing (and it must have the required CPS score)
- If you’re joining the combination parts (gastric/GEJ/esophagus, pancreas, or biliary tract cancer), your tumor must be CLDN18.2-positive
- You must not have had previous treatments that target CLDN18.2 or 4-1BB (two specific immune-related medicines)
- For the combination parts, you must not have previously received an anti–PD-1 or anti–PD-L1 drug
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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