RPH-104 to prevent repeat fevers in colchicine-resistant FMF
Part of Genetic & congenital clinical trials.
This Phase 2 study tests whether RPH-104 can help prevent recurrent fever attacks in adults with Familial Mediterranean Fever (FMF) who cannot tolerate colchicine or whose disease does not respond to it. Participants may receive the medicine at the clinic or learn to give it as a self-injection, depending on what fits your situation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have FMF and either cannot tolerate colchicine or it does not work for you, and you finished the earlier core study and had at least one RPH-104 dose there.
- You sign and date the consent form and are willing to follow the study plan.
- You must be able to get RPH-104 every 2 weeks at the study site, or learn self-injection, or agree to have a clinician visit you at home.
- If you can become pregnant or you are a sexually active man, you must use highly effective birth control during the study and for at least 8 weeks after your last dose.
- You must not be pregnant or breastfeeding, and you must avoid pregnancy during the study and for 2 months after your last dose.
- You cannot take certain immune-suppressing medicines, biologic drugs, or other study medicines besides RPH-104 during the study period, and you cannot get live (attenuated) vaccines during the study or for 3 months after the last dose.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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