Trial of anakinra for FMF attacks in patients who refuse daily shots
Treatments studied
Part of Genetic & congenital clinical trials.
This trial tests if taking anakinra (a targeted medicine) only when you have a painful FMF attack can help, instead of taking it every day. It is for people with Familial Mediterranean Fever (FMF) whose attacks continue despite taking colchicine, and who do not want daily injections.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 6 years or older
- You have been diagnosed with FMF by specific criteria and have two proven MEFV gene changes
- You still get FMF attacks (like arthritis, chest pain, belly pain, muscle pain, or skin redness lasting 1–4 days) at least once a month even on the highest dose of colchicine
- You have decided not to take daily anakinra shots
- You do not have active tuberculosis or frequent severe infections
- You are not pregnant and are willing to use effective birth control if needed
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests whether RPH-104 can help prevent recurrent fever attacks in adults with Familial Mediterranean Fever (FMF) who cannot tolerate colchicine or whose disease does not respond to it. Participants may receive the medicine at the clinic or learn to give it as a self-injection, depending on what fits your situation.
This study tests a medicine called anakinra that may reduce heart swelling in children with a severe heart condition called acute myocarditis. It might help their heart recover faster while they are in the intensive care unit.
This study looks at the gut bacteria (microbiome) in people with autoinflammatory diseases. It may help researchers understand how bacteria in the gut affect inflammation and find better ways to treat these conditions.
This study looks at how well and safely different real-world treatments work for people with Familial Mediterranean Fever (FMF). It aims to find which medicines help best for this inherited inflammatory disorder.
This study tests whether a drug called anakinra, given as a shot, can help treat moderate asthma attacks right when they happen, reducing the need for other rescue treatments. It may help people whose asthma is not well controlled and who have needed steroids in the past year.
This trial tests an anti-inflammatory drug (anakinra) in people whose inner-ear hearing problems have not improved with steroid treatment. It aims to reduce worsening hearing caused by autoimmune inner ear disease or difficult-to-control Meniere’s disease.
Hear when a new FMF trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.