Pyridostigmine to treat slow bowel recovery after colorectal surgery
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether pyridostigmine helps return bowel function faster after colorectal surgery when the gut is “stuck,” causing bloating and no gas or stool. It also checks safety and side effects compared with standard care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 or older and had colon or rectal surgery (open, laparoscopic, or robotic) for benign or cancer reasons
- After surgery, you have signs of ileus: bloating (with or without nausea/vomiting) and no gas (flatus) or stool for at least 48 hours, and you must go back to nothing by mouth (NPO) after trying food; sometimes a tube (NGT) is used
- Tests like an abdominal X-ray or CT scan confirm you have ileus (but not a blockage)
- You have no serious infection-related problems in the belly (like abscess, peritonitis, or an anastomotic leak) before or after starting the study
- Your bloodwork and organ function are in safe ranges (blood counts, liver enzymes, bilirubin, and kidney function)
- You’re able to take part as planned (and are not using certain other bowel-movement medications or other study drugs)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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