Regorafenib plus aspirin then standard chemo for metastatic bowel cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests whether adding regorafenib and low-dose aspirin before standard chemotherapy can slow metastatic colorectal cancer after it has progressed on prior treatment. It may help by trying a different cancer-fighting approach earlier, followed by the usual chemo plan.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have metastatic colorectal cancer confirmed by pathology (a biopsy/piece of tumor)
- Your cancer has already progressed after first-line chemo, and you received one of several specific first treatments
- Your cancer must match a specific “not working” pattern (progression within 3 months, or relapse within 6 months) after that earlier treatment
- Tumor tests must show microsatellite-stable (MSS), no BRAF V600E mutation, and a known RAS status
- You must be well enough to take treatment (age 18+, and general function score of 0–1) and have measurable tumor on scans
- Your blood, kidney, and liver tests must be within required safety limits, and you must not be pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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