Mirikizumab for children with active Crohn’s disease
Treatments studied
Part of Digestive system clinical trials.
This study tests mirikizumab to reduce inflammation and symptoms in children with Crohn’s disease that is currently active. It may help if your Crohn’s has not improved enough (or stopped working) with at least one other Crohn’s medicine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child has Crohn’s disease (including fistulizing Crohn’s) confirmed by doctors using past exams and biopsy results
- Crohn’s is currently moderately to severely active, based on a pediatric Crohn’s activity score of 30 or higher
- Within 1 month of starting the study, endoscopy shows active disease (using a scoring system like SES-CD)
- Your child has tried at least one Crohn’s medicine before and had not enough benefit, or lost benefit, or had side effects (including steroids, immunomodulators, biologics, or JAK inhibitors)
- Your child does not have certain Crohn’s complications that may need surgery soon, like symptomatic narrowing/strictures, short bowel, or other surgery-planning problems
- Your child does not have a bowel abscess, and has not had bowel surgery in the last 26 weeks or other abdominal surgery in the last 12 weeks
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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