Study of an antibody medicine with or without chemotherapy for relapsed lymphoma
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests glofitamab alone or with chemotherapy and immunotherapy in children and young adults whose “mature B-cell” non-Hodgkin lymphoma has come back or hasn’t responded to treatment. It looks at whether the study medicines can shrink lymphoma again and are safe enough to use in this age group.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re between 6 months and under 18 years (or under 30 for one study part) when you sign consent.
- Your lymphoma has been confirmed on tissue/biopsy or fluid sample and it shows CD20 on the tumor cells.
- Your cancer must be relapsed (came back) or refractory (didn’t respond), and you’ve had the required number of prior standard treatments for your study group.
- You must have measurable lymphoma (a lymph node/spot large enough, or measurable bone marrow involvement).
- Your overall activity level is sufficient (Lansky/Karnofsky score meeting the study cutoff).
- Recent blood tests must show your bone marrow, liver, and kidneys can handle study treatment; also you must be negative for hepatitis B/C and be HIV-negative (with limited exceptions).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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