Trial of an oral pill for MAPK-driven advanced solid tumors
Part of Cancer clinical trials.
This Phase 1 study tests an oral investigational medicine (JZP815) to see how safe it is, the best dose, and whether it can shrink tumors. It’s for adults with advanced or metastatic solid cancers that have a specific MAPK pathway genetic change.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 years or older and able to sign consent
- Have advanced or metastatic solid cancer with a documented MAPK pathway genetic change
- Have tried standard treatments already, or be unlikely to benefit or tolerate them
- Be well enough to do daily activities (ECOG 0–1; Arm 7 may allow 0–2)
- Have measurable tumors that can be followed on scans
- Be able to take the study pill and likely have at least 12 weeks of life expectancy
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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