Zoledronic acid in bone cement after tumor scraping
Part of Cancer clinical trials.
This trial tests whether adding zoledronic acid (a bone-strengthening medicine) into bone cement at the surgical site can help prevent giant cell bone tumor from coming back after surgeons scrape it out from inside the bone. It is for people whose tumor can be treated with a specific “scrape-and-reconstruct” surgery and who have not had related medicines before.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a primary (first-time) giant cell tumor of bone.
- Your tumor can be treated with intralesional curettage (scraping out from inside) with enough intact bone left to reconstruct the area.
- You have not taken denosumab or bisphosphonate medicines before (including zoledronic acid).
- Your doctor expects you will live longer than 18 months.
- You are able and willing to sign the informed consent form and do follow-up check-ins after surgery.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at whether taking a bone-strengthening medicine called a bisphosphonate after surgery can lower the chance that a giant cell tumor in a leg or arm comes back. It may help prevent recurrence after removing the tumor from the bone.
This study tests an experimental medication (JMT103) for people with giant cell tumor of bone that cannot be safely removed with surgery. The drug may help shrink the tumor or slow its growth, providing an option when surgery is too risky.
This study tests whether zoledronic acid, a medicine given by IV, helps prevent bone problems in women with breast cancer that has spread to the bones. It looks at how well the drug works in a real-world setting to reduce the risk of fractures or other bone issues.
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